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YARHomo sapiens (Human)Transformed cell line

🤖 AI SummaryBased on 4 publications

Quick Overview

YAR is a B-lymphoblastoid cell line derived from the 10th International Histocompatibility Workshop, used for HLA typing and im...

Detailed Summary

YAR is a B-lymphoblastoid cell line established as part of the 10th International Histocompatibility Workshop panel, widely used for HLA typing and immunogenetics research. It is characterized by its homozygous HLA alleles, making it a valuable reference for studying HLA class I and II genes. The cell line has been extensively analyzed for HLA polymorphism and has contributed to the development of high-resolution typing methods such as SMRT sequencing and SSOP hybridization. YAR is particularly useful for understanding HLA allele associations and linkage disequilibrium patterns, and has been used in studies to identify novel alleles and intronic variants. Its well-characterized HLA profile makes it a key resource for transplantation medicine and immunogenetics research.

Research Applications

HLA typing and immunogenetics researchAnalysis of HLA class I and II allelesStudy of HLA polymorphism and linkage disequilibriumDevelopment of high-resolution typing methods

Key Characteristics

Homozygous for HLA allelesUsed in the 10th International Histocompatibility Workshop panelContributed to the identification of novel HLA alleles and variants
Generated on 6/18/2025

Basic Information

Database IDCVCL_2192
SpeciesHomo sapiens (Human)
Tissue SourcePeripheral blood[UBERON:UBERON_0000178]

Disease Information

DepMap Information

Publications

Next-generation HLA typing of 382 International Histocompatibility Working Group reference B-lymphoblastoid cell lines: report from the 17th International HLA and Immunogenetics Workshop.

Fernandez-Vina M.A.

Hum. Immunol. 80:449-460(2019).

DOIPubMedPMC

Single molecule real-time DNA sequencing of HLA genes at ultra-high resolution from 126 international HLA and immunogenetics workshop cell lines.

Robinson J., Madrigal J.A., Mayor N.P., Marsh S.G.E.

HLA 91:88-101(2018).

DOIPubMed

Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.

Parham P.

Genome Res. 27:813-823(2017).

DOIPubMedPMC

Allele assignment for HLA-A, -B, and -C genes to the Tenth International Histocompatibility Workshop cell lines.

Prasad V.K., Yang S.Y.

Tissue Antigens 47:538-546(1996).

DOIPubMed

Characterization of 4AOHW cell line panel including new data for the 10IHW panel.

Carcassi C., Albert E.D., Giphart M.J., Dawkins R.L.

Hum. Immunol. 38:3-16(1993).

DOIPubMed

Assignment of T-cell-defined (TCD) HLA class II specificities for the reference panel of B-lymphoblastoid cell lines.

Flomenberg N.

(In book chapter) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont B. (eds.); pp.46-48; Springer; New York; USA (1989).

DOI

Assignment of HLA-class II alpha and beta chain 2-D gel patterns for the workshop reference panel of B-lymphoblastoid cell lines.

Knowles R.W.

(In book chapter) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont B. (eds.); pp.44-46; Springer; New York; USA (1989).

DOI

Assignment of HLA-A and HLA-B antigens for the reference panel of B-lymphoblastoid cell lines determined by one-dimensional isoelectric focusing (lD-IEF) gel electrophoresis.

Yang S.Y.

(In book chapter) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont B. (eds.); pp.43-44; Springer; New York; USA (1989).

DOI

HLA-Dw and HLA-DP typing of the reference panel of B-lymphoblastoid cell lines.

Eckels D.D.

(In book chapter) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont B. (eds.); pp.38-42; Springer; New York; USA (1989).

DOI

Description of the reference panel of B-lymphoblastoid cell lines for factors of the HLA system: the B-cell line panel designed for the Tenth International Histocompatibility Workshop.

Yang S.Y., Milford E.L., Hammerling U., Dupont B.

(In book chapter) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont B. (eds.); pp.11-19; Springer; New York; USA (1989).

DOI