SiSoHomo sapiens (Human)Cancer cell line
Also known as: SISO
🤖 AI SummaryBased on 2 publications
Quick Overview
Human uterine cervical adenocarcinoma cell line for cancer research.
Detailed Summary
The SiSo cell line is derived from a human uterine cervical adenocarcinoma and is used in cancer research. It expresses tumor-associated antigens such as CA125, CEA, and GA733, and is sensitive to certain anti-cancer reagents. The cell line has been characterized for its growth properties, surface antigens, and response to chemotherapy. It provides a model for studying the biological characteristics and therapeutic responses of uterine cervical adenocarcinoma. Additionally, the SiSo cell line has been used to investigate the effects of anti-cancer drugs on tumor marker secretion and cell viability.
Research Applications
Cancer researchTumor marker studiesChemotherapy sensitivity testingDrug resistance mechanisms
Key Characteristics
Expresses MHC class I antigensExpresses adhesion molecules (ICAM-1, LFA-1, LFA-3)Secretes tumor-associated antigens (CA125, CEA, GA733)Shows resistance to multiple anti-cancer reagentsEstablished from a primary tumor site
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2193 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Uterus, cervix[UBERON:UBERON_0000002] |
Donor Information
| Age | 67 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Human papillomavirus-related cervical adenocarcinoma |
|---|---|
| Lineage | Cervix |
| Subtype | Cervical Adenocarcinoma |
| OncoTree Code | CEAD |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001650_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | RB1 | p.Ser834Ter (c.2501C>G) | Homozygous | - | Unknown, Unknown |
| MutationSimple | KRAS | p.Gly12Asp (c.35G>A) | Unspecified | - | PubMed=29786757 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,12
D13S317
11
D16S539
9
D18S51
14,16
D19S433
14
D21S11
30,31
D2S1338
19
D3S1358
15
D5S818
9,12
D7S820
11,12
D8S1179
12
FGA
23
Penta D
11,13
Penta E
11,13
TH01
7
TPOX
11
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Establishment, authenticity, and characterization of cervical cancer cell lines.
Garcia-Carranca A.M., Cerbon-Cervantes M.A., Alcantara-Quintana L.E.
Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).