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SU-DHL-8Homo sapiens (Human)Cancer cell line

Also known as: DHL8, DHL-8, Stanford University-Diffuse Histiocytic Lymphoma-8, SuDHL 8, SUDHL-8, SUDHL8

🤖 AI SummaryBased on 10 publications

Quick Overview

SU-DHL-8 is a human diffuse histiocytic lymphoma cell line derived from a patient with intermediate-grade, large cell lymphoma.

Detailed Summary

SU-DHL-8 is a cell line established from a patient with diffuse histiocytic lymphoma, classified as intermediate-grade, diffuse large cell (class G) type. It is one of 15 cell lines studied for their immunologic and cytogenetic characteristics. The cell line exhibits B-cell origin, as determined by surface immunoglobulin studies. Cytogenetic analysis revealed complex chromosomal abnormalities, including trisomy of chromosome 12 and other rearrangements. The cell line is used in research to study the genetic and immunologic features of lymphoid malignancies, particularly focusing on chromosomal translocations and their implications in lymphoma development.

Research Applications

Immunologic studiesCytogenetic analysisChromosomal translocation researchLymphoma genetics

Key Characteristics

B-cell originTrisomy of chromosome 12Complex chromosomal rearrangementsIntermediate-grade lymphoma

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2207
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	59
Age Category	Adult
Sex	Male

Disease Information

Disease	Diffuse large B-cell lymphoma
Lineage	Lymphoid
Subtype	Diffuse Large B-Cell Lymphoma, NOS
OncoTree Code	DLBCLNOS

DepMap Information

Source Type	DSMZ
Source ID	ACH-000656_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg249Gly (c.745A>G)	Heterozygous	-	from parent cell line SU-DHL-8
MutationSimple	TP53	p.Tyr234Asn (c.700T>A)	Heterozygous	-	from parent cell line SU-DHL-8
MutationSimple	KMT2D	p.Pro648Thrfs*2 (c.1940dupC) (c.1940_1941insC)	Heterozygous	-	from parent cell line SU-DHL-8

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

11,12

D13S317

11,13

D16S539

12

D18S51

14,19

D19S433

13

D21S11

30,31.2

D2S1338

17,20

D3S1358

14,15

D5S818

11,13

D7S820

8

D8S1179

13

FGA

25

Penta D

11,12

Penta E

14,17

TH01

6,9

TPOX

8

vWA

15,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

Kutok J.L., Shipp M.A.

Blood 116:3268-3277(2010).

Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.

Robetorye R.S., Aguiar R.C.T.

Blood 113:6681-6690(2009).

Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.

Uppenkamp M.J., Nowrousian M.R., Seeber S., Opalka B.

Br. J. Haematol. 91:350-354(1995).

Histiocytic lymphoma cell lines: immunologic and cytogenetic studies.

Hecht F.

Cancer Genet. Cytogenet. 14:205-218(1985).

Feeder layer and nutritional requirements for the establishment and cloning of human malignant lymphoma cell lines.

Epstein A.L., Kaplan H.S.

Cancer Res. 39:1748-1759(1979).

Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines.

Epstein A.L., Levy R., Kim H., Henle W., Henle G.S., Kaplan H.S.

Cancer 42:2379-2391(1978).

Biology of the human malignant lymphomas. III. Intracranial heterotransplantation in the nude, athymic mouse.

Epstein A.L., Herman M.M., Kim H., Dorfman R.F., Kaplan H.S.

Cancer 37:2158-2176(1976).

Biology and virology of the human malignant lymphomas: 1st Milford D. Schulz Lecture.

Kaplan H.S., Goodenow R.S., Gartner S., Bieber M.M.

Cancer 43:1-24(1979).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

Web Resources