SUP-M2Homo sapiens (Human)Cancer cell line

Also known as: SUPM2, Sup-M2

🤖 AI SummaryBased on 7 publications

Quick Overview

Human lymphoma cell line with NPM-ALK fusion protein

Detailed Summary

SUP-M2 is a human lymphoma cell line derived from a patient with anaplastic large cell lymphoma (ALCL). This cell line is characterized by the presence of the NPM-ALK fusion protein, which results from the t(2;5) chromosomal translocation. The NPM-ALK fusion protein is a constitutively active tyrosine kinase that plays a critical role in the oncogenic transformation of the cells. Research on SUP-M2 has focused on understanding the mechanisms of NPM-ALK-mediated transformation, including its role in cell proliferation, survival, and resistance to apoptosis. The cell line is also used to study the effects of targeted therapies against the NPM-ALK fusion protein. SUP-M2 has been utilized in studies examining the subcellular localization of NPM-ALK, its interaction with wild-type NPM, and the activation of downstream signaling pathways such as the JAK-STAT and MAPK pathways. Additionally, the cell line has been employed in investigations of the role of NPM-ALK in tumor progression and metastasis.

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2209
Species	Homo sapiens (Human)
Tissue Source	Cerebrospinal fluid[UBERON:UBERON_0001359]

Donor Information

Age	5
Age Category	Pediatric
Sex	Female

Disease Information

Disease	ALK-positive anaplastic large cell lymphoma
Lineage	Lymphoid
Subtype	Anaplastic Large-Cell Lymphoma ALK Positive
OncoTree Code	ALCLALKP

DepMap Information

Source Type	DSMZ
Source ID	ACH-000226_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
Gene fusion	ALK	NPM1-ALK	-	-	PubMed=9121481, PubMed=7824924

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

10,11

D16S539

11,12

D18S51

12,14

D19S433

14,15

D21S11

29,30

D2S1338

17,20

D3S1358

15,17

D5S818

D7S820

8,12

D8S1179

14,15

FGA

21,22

Penta D

11,12

Penta E

7,16

TH01

8,9.3

TPOX

8,10

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Malignant hematopoietic cell lines: in vitro models for the study of anaplastic large-cell lymphoma.

Drexler H.G., MacLeod R.A.F.

Leukemia 18:1569-1571(2004).

DOI PubMed

Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis.

Bischof D., Pulford K., Mason D.Y., Morris S.W.

Mol. Cell. Biol. 17:2312-2325(1997).

DOI PubMed PMC

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

Look A.T., Saltman D.L.

Science 267:316-317(1995).

DOI PubMed

Lack of involvement of the c-fms and N-myc genes by chromosomal translocation t(2;5)(p23;q35) common to malignancies with features of so-called malignant histiocytosis.

Mellentin J.D., Warnke R.A., Cleary M.L.

Blood 73:2155-2164(1989).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

tcpaportal.org