SUP-T11Homo sapiens (Human)Cancer cell line

Also known as: Stanford University Pediatric T-cell line 11, SUPT-11, SUPT11, SupT11

🤖 AI SummaryBased on 4 publications

Quick Overview

Human T cell line for cancer research and drug development

Detailed Summary

SUP-T11 is a human T cell line derived from a T-cell acute lymphoblastic leukemia (T-ALL) patient. This cell line is widely used in cancer research, particularly in studies related to T-cell malignancies and immunotherapy. It provides a valuable model for investigating the molecular mechanisms of T-ALL and evaluating potential therapeutic strategies. The cell line is characterized by its ability to grow in culture and its genetic stability, making it a reliable tool for in vitro studies. Research on SUP-T11 has contributed to understanding the role of NOTCH1 mutations in T-ALL pathogenesis and the development of targeted therapies. Additionally, its use in drug screening assays has facilitated the identification of novel compounds with anti-cancer properties.

Research Applications

Cancer researchImmunotherapy studiesDrug developmentMolecular mechanism investigation

Key Characteristics

Human T cell lineDerived from T-ALL patientUsed in T-cell malignancy studiesGenetic stability in cultureRelevant for NOTCH1 mutation research

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2210
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	74
Age Category	Adult
Sex	Male
Subtype Features	TAL1

Disease Information

Disease	Precursor T-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	Adult T-Cell Leukemia/Lymphoma
OncoTree Code	ATLL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000122_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg249Ser (c.747G>C)	Homozygous	-	Unknown
MutationSimple	TP53	p.Arg213Ter (c.637C>T)	Unspecified	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

10,12

D16S539

11,13

D18S51

17,18

D19S433

14,15

D21S11

D2S1338

24,25

D3S1358

14,18

D5S818

D7S820

9,12

D8S1179

12,14

FGA

21,22

Penta D

11,14

Penta E

TH01

6,9.3

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.

Science 306:269-271(2004).

DOI PubMed

Long-term growth of malignant thymocytes in vitro.";

Sklar J.

Blood 73:2182-2187(1989).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI