TT2609-C02Homo sapiens (Human)Cancer cell line

Also known as: TT2609C02, TT2609-CO2

🤖 AI SummaryBased on 9 publications

Quick Overview

Human follicular thyroid cancer cell line with distinct biological characteristics.

Detailed Summary

TT2609-C02 is a human follicular thyroid cancer cell line derived from a single tumor recurrence. It exhibits unique morphological and functional properties, including distinct proliferation rates, cytoplasmic thyroglobulin (Tg) expression, and tumorigenic potential in nude mice. The cell line shows a 4n ploidy state and lacks tumorigenicity in some in vivo models. It is part of a panel of three clonally related but phenotypically divergent cell lines, providing a valuable resource for studying thyroid cancer biology and therapeutic strategies.

Research Applications

Cancer biology researchTherapeutic drug testingTumor heterogeneity studies

Key Characteristics

4n ploidy stateCytoplasmic Tg expressionTumorigenic in nude miceDistinct proliferation rate

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2218
Species	Homo sapiens (Human)
Tissue Source	Thyroid gland[UBERON:UBERON_0002046]

Donor Information

Age	57
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Differentiated thyroid carcinoma
Lineage	Thyroid
Subtype	Follicular Thyroid Cancer
OncoTree Code	THFO

DepMap Information

Source Type	DSMZ
Source ID	ACH-000716_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ile254Thr (c.761T>C)	Heterozygous	-	Unknown
MutationSimple	TP53	p.Arg273Cys (c.817C>T)	Homozygous	-	PubMed=35933914
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	NRAS	p.Gln61Arg (c.182A>G)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

11,13

D16S539

9,11

D18S51

D19S433

13,15

D21S11

28,30

D2S1338

19,25

D3S1358

D5S818

D7S820

8,10

D8S1179

12,13

FGA

22,25

Penta D

12,14

Penta E

TH01

8,9.3

TPOX

8,12

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Targeted treatment options of recurrent radioactive iodine refractory Hurthle cell cancer.

Solleveld-Westerink N., van Wezel T., Kapiteijn E.H.W., Morreau H.

Cancers (Basel) 11:1185.1-1185.16(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.

Fagin J.A., Schweppe R.E.

Clin. Cancer Res. 25:3141-3151(2019).

DOI PubMed PMC

ROS-induced near-homozygous genomes in thyroid cancer.";

van Wezel T., Morreau H.

Endocr. Relat. Cancer 25:83-97(2018).

DOI PubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.

Tun H.W., Smallridge R.C., Copland J.A. 3rd

J. Clin. Endocrinol. Metab. 100:E697-E709(2015).

DOI PubMed PMC

Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.

Ibrahimpasic T., Ghossein R.A., Fagin J.A.

J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.

Haugen B.R.

J. Clin. Endocrinol. Metab. 93:4331-4341(2008).

DOI PubMed PMC

Clonally related but phenotypically divergent human cancer cell lines derived from a single follicular thyroid cancer recurrence (TT2609).

Lips P., Teule G.J.J.

Thyroid 11:909-917(2001).

DOI PubMed