U-HO1Homo sapiens (Human)Cancer cell line
Also known as: UHO1, U-H01
🤖 AI SummaryBased on 5 publications
Quick Overview
U-HO1 is a Hodgkin lymphoma cell line derived from a refractory classical Hodgkin lymphoma.
Detailed Summary
U-HO1 is a cell line derived from a primary refractory classical Hodgkin lymphoma (cHL) patient. It exhibits characteristics typical of Hodgkin lymphoma, including the expression of CD30 and CD15, and lacks HLA-A, B, C. The cell line has a hyperdiploid karyotype with multiple clonal aberrations, including an elongated chromosome 2 with specific translocations. U-HO1 is EBV-negative and shows a relatively simple karyotype compared to other HL cell lines, making it a valuable model for studying cHL. It has been used in research on the molecular mechanisms of Hodgkin lymphoma, including studies on NF-κB activation and the role of A20 in tumor suppression.
Research Applications
Study of Hodgkin lymphoma molecular mechanismsInvestigation of NF-κB activationAnalysis of A20 tumor suppressor function
Key Characteristics
EBV-negativeExpresses CD30 and CD15HLA-A, B, C negativeHyperdiploid karyotypeRelatively simple karyotype compared to other HL cell lines
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2220 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 23 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Hodgkin lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Hodgkin Lymphoma |
| OncoTree Code | HL |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001685_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TNFAIP3 | p.Met43fs (c.127-134del) (del 193-200) | Heterozygous | - | PubMed=19380639 |
| Gene deletion | TNFAIP3 | - | Heterozygous | - | PubMed=19380639 |
| MutationUnexplicit | PTPN1 | Ex2-8del | Unspecified | - | CelloPub=CLPUB00457 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10
D13S317
11,12
D16S539
11,13
D18S51
14
D19S433
13,14
D21S11
30,32.2
D2S1338
23,24
D3S1358
13,17
D5S818
11
D7S820
8,10
D8S1179
13,16
FGA
21,24
Penta D
9,13
Penta E
5,18
TH01
7,9.3
TPOX
8,10
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Biol. Chem. 399:511-523(2018).
3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including 't-stumps'.
Lichtensztejn Z., Lemieux B., Moller P., Mai S.
BMC Cell Biol. 11:99.1-99.10(2010).
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
Stanelle J., Siebert R., Kuppers R.
J. Exp. Med. 206:981-989(2009).
U-HO1. A new cell line derived from a primary refractory classical Hodgkin lymphoma.
Moller P., Mader A., Barth T.F.E., Bruderlein S.
Pathologe 29 Suppl. 2:317-318(2008).
Anecdotal Information
- Andreas Mader, the first author of the paper (PubMed=18253030) describing this cell line is the patient that donated the cell line. As it is not frequent to see a patient 'acknowledged' by being an author this fact should be emphasized