UPCI-SCC-026Homo sapiens (Human)Cancer cell line
Also known as: SCC026, UPCISCC026, UPCI:SCC026
🤖 AI SummaryBased on 1 publications
Quick Overview
Human oral squamous cell carcinoma cell line with 11q13 amplification.
Detailed Summary
UPCI-SCC-026 is a human oral squamous cell carcinoma cell line characterized by chromosomal abnormalities, including amplification of the 11q13 region. This cell line was part of a study examining chromosomal imbalances in oral squamous cell carcinoma, where it was noted for its 11q13 amplification, a common genetic alteration associated with tumor progression. The cell line's karyotype showed nonrandom chromosomal losses and gains, with a focus on 3p, 9p, 11q, and 18q regions. The study validated the use of such cell lines as in vitro models for research into head and neck squamous cell carcinoma, highlighting their utility in understanding genetic changes linked to cancer development and progression.
Research Applications
Cancer researchGenetic analysisIn vitro modeling of head and neck squamous cell carcinoma
Key Characteristics
Amplification of 11q13 regionChromosomal imbalances including 3p, 9p, 11q, and 18qNonrandom chromosomal abnormalities
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2221 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, alveolar ridge[UBERON:UBERON_0004103] |
Donor Information
| Age | 82 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001690_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,13
D13S317
8,11
D16S539
11,12
D18S51
17
D19S433
15
D21S11
31
D2S1338
20,24
D3S1358
16
D5S818
13
D7S820
10
D8S1179
13
FGA
23,25
Penta D
11
Penta E
10,13
TH01
9.3
TPOX
8,9
vWA
15,18
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.
Reddy J.K., Khanna P., Johnson J.T., Myers E.N., Gollin S.M.
Oral Oncol. 44:369-382(2008).