UPCI-SCC-040Homo sapiens (Human)Cancer cell line
Also known as: SCC040, UPCISCC040, UPCI:SCC040
🤖 AI SummaryBased on 2 publications
Quick Overview
Human oral squamous cell carcinoma cell line with 11q13 amplification and chromosomal instability.
Detailed Summary
UPCI-SCC-040 is a human oral squamous cell carcinoma (OSCC) cell line derived from a primary tumor. It exhibits significant chromosomal instability, including gains and losses across multiple chromosomes. Notably, it shows amplification of the 11q13 region, which is associated with poor prognosis and tumor progression. This cell line has been used in studies to investigate chromosomal abnormalities, gene amplification, and their implications in head and neck cancer development. Research has highlighted its utility in understanding the molecular mechanisms of OSCC, particularly in relation to the ATR-CHEK1 pathway and DNA repair processes. The cell line's characteristics make it a valuable tool for studying tumor biology and therapeutic resistance.
Research Applications
Chromosomal instability analysisGene amplification studiesHead and neck cancer researchDNA repair mechanismsATR-CHEK1 pathway investigation
Key Characteristics
11q13 amplificationChromosomal gains and lossesHigh chromosomal instabilityAmplification of ATR and CHEK1 genes
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2222 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, tongue[UBERON:UBERON_0001723] |
Donor Information
| Age | 50 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral tongue |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001692_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12
D13S317
8,12
D16S539
11
D18S51
10
D19S433
13
D21S11
30
D2S1338
17,20
D3S1358
17
D5S818
10,11
D7S820
9,10
D8S1179
14
FGA
20,21
Penta D
9
Penta E
12
TH01
6,8
TPOX
11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas.
Vlad A., Gollin S.M.
Genes Chromosomes Cancer 53:25-37(2014).
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.
Reddy J.K., Khanna P., Johnson J.T., Myers E.N., Gollin S.M.
Oral Oncol. 44:369-382(2008).