UPCI-SCC-072Homo sapiens (Human)Cancer cell line
Also known as: SCC072, UPCI:SCC072
🤖 AI SummaryBased on 2 publications
Quick Overview
Human oral squamous cell carcinoma cell line with 11q13 amplification.
Detailed Summary
UPCI-SCC-072 is a human oral squamous cell carcinoma cell line derived from a patient with head and neck cancer. This cell line exhibits significant chromosomal abnormalities, including amplification of the 11q13 region, which is associated with tumor progression and poor prognosis. The cell line has been used in studies examining genetic changes in head and neck squamous cell carcinomas, particularly focusing on chromosomal imbalances and gene amplifications. Research has shown that UPCI-SCC-072 displays nonrandom chromosomal losses and gains, with 11q13 amplification being a notable feature. These characteristics make it a valuable model for studying the molecular mechanisms underlying head and neck cancer development and progression.
Research Applications
Chromosomal imbalances in head and neck squamous cell carcinomaGene amplification studies (e.g., 11q13)Molecular cytogenetic analysis
Key Characteristics
Amplification of 11q13 regionNonrandom chromosomal losses and gainsUsed in studies of head and neck cancer progression
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2223 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, tonsil[UBERON:UBERON_0002372] |
Donor Information
| Age | 61 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001693_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.His179Asn (c.535C>A) | Unspecified | - | PubMed=12872257 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
11
D16S539
11,12
D18S51
12,16
D19S433
13
D21S11
17,24
D2S1338
17,24
D3S1358
17
D5S818
14
D7S820
11,12
D8S1179
13,15
FGA
21,23
Penta D
13
Penta E
5,7
TH01
6
TPOX
8
vWA
15
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.
Reddy J.K., Khanna P., Johnson J.T., Myers E.N., Gollin S.M.
Oral Oncol. 44:369-382(2008).
The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines.
Gollin S.M.
Oral Oncol. 43:701-712(2007).