UPCI-SCC-074Homo sapiens (Human)Cancer cell line
Also known as: SCC074, UPCISCC074, UPCI:SCC074
🤖 AI SummaryBased on 1 publications
Quick Overview
Human oral squamous cell carcinoma cell line with 11q13 amplification.
Detailed Summary
UPCI-SCC-074 is a human oral squamous cell carcinoma cell line characterized by chromosomal abnormalities, including amplification of the 11q13 region. This cell line was analyzed in a study examining chromosomal imbalances in oral squamous cell carcinoma, where it was found to exhibit nonrandom chromosomal gains and losses. The 11q13 amplification is a notable feature, which may have implications for tumor progression and prognosis. The cell line's genetic profile supports its use as a model for studying head and neck squamous cell carcinoma.
Research Applications
Cancer researchGenetic analysisHead and neck squamous cell carcinoma modeling
Key Characteristics
Chromosomal abnormalities11q13 amplification
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2224 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, alveolar ridge[UBERON:UBERON_0004103] |
Donor Information
| Age | 51 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001694_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg273His (c.818G>A) | Homozygous | - | Unknown, PubMed=16264262 |
| MutationSimple | TP53 | p.Lys132Asn (c.396G>T) | Heterozygous | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
10,11
D16S539
9,10
D18S51
16
D19S433
13,15
D21S11
30.2,31.2
D2S1338
20
D3S1358
15
D5S818
11
D7S820
8,11
D8S1179
10,15
FGA
20,24
Penta D
6,8
Penta E
7,13
TH01
7,9.3
TPOX
9,11
vWA
15,17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.
Reddy J.K., Khanna P., Johnson J.T., Myers E.N., Gollin S.M.
Oral Oncol. 44:369-382(2008).