UPCI-SCC-099Homo sapiens (Human)Cancer cell line
Also known as: SCC099, UPCI:SCC099
🤖 AI SummaryBased on 3 publications
Quick Overview
Human oral squamous cell carcinoma cell line with 11q13 amplification and chromosomal instability.
Detailed Summary
UPCI-SCC-099 is a human oral squamous cell carcinoma (OSCC) cell line derived from a primary tumor. It exhibits significant chromosomal instability, including gains and losses across multiple chromosomes, with a notable amplification of the 11q13 region. This cell line is frequently used in research to study the genetic alterations associated with head and neck squamous cell carcinomas (HNSCC), particularly focusing on the role of 11q13 amplification in tumor progression. The cell line has been utilized in studies examining the ATR-CHEK1 pathway, which is upregulated in response to DNA damage and contributes to radioresistance. UPCI-SCC-099 is also valuable for investigating the molecular mechanisms of chromosomal instability and its impact on cancer development and treatment response.
Research Applications
Chromosomal instability analysis11q13 amplification studiesATR-CHEK1 pathway investigationRadioresistance mechanisms
Key Characteristics
Chromosomal gains and losses11q13 amplificationHigh chromosomal instabilityUpregulated ATR-CHEK1 pathway
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2225 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, floor of mouth[UBERON:UBERON_0003679] |
Donor Information
| Age | 52 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001695_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Pro177Arg (c.530C>G) | Unspecified | - | PubMed=12872257 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
8,13
D16S539
11,12
D18S51
13
D19S433
14,16
D21S11
28
D2S1338
18
D3S1358
16
D5S818
11,12
D7S820
7,9,10
D8S1179
13
FGA
23,23.2
Penta D
9
Penta E
7,8
TH01
6,9.3
TPOX
11
vWA
14,18,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas.
Vlad A., Gollin S.M.
Genes Chromosomes Cancer 53:25-37(2014).
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.
Reddy J.K., Khanna P., Johnson J.T., Myers E.N., Gollin S.M.
Oral Oncol. 44:369-382(2008).
The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines.
Gollin S.M.
Oral Oncol. 43:701-712(2007).