UPCI-SCC-111Homo sapiens (Human)Cancer cell line
Also known as: SCC-111, SCC111, UPCI:SCC111
🤖 AI SummaryBased on 2 publications
Quick Overview
Human oral squamous cell carcinoma cell line with 11q13 amplification.
Detailed Summary
UPCI-SCC-111 is a human oral squamous cell carcinoma cell line derived from a patient with head and neck cancer. This cell line exhibits significant chromosomal abnormalities, including amplification of the 11q13 region, which is associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC). The cell line has been used in studies examining genetic alterations and their implications in tumor progression. Research has shown that UPCI-SCC-111 displays clonal chromosomal abnormalities, with consistent gains and losses observed across multiple passages. The presence of 11q13 amplification suggests its potential role in cancer development and progression. Additionally, the cell line has been utilized to study the relationship between chromosomal instability and tumor aggressiveness.
Research Applications
Chromosomal instability analysisGene amplification studiesHead and neck cancer researchTumor progression studies
Key Characteristics
11q13 amplificationChromosomal abnormalitiesClonal chromosomal instability
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2226 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, floor of mouth[UBERON:UBERON_0003679] |
Donor Information
| Age | 69 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001696_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.His179Tyr (c.535C>T) | Unspecified | - | PubMed=12872257 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
11,13
D16S539
9,12
D18S51
16.2
D19S433
14
D21S11
29,30,31
D2S1338
19,26
D3S1358
17
D5S818
12
D7S820
8,10
D8S1179
13,14
FGA
20
Penta D
11,14
Penta E
13
TH01
8,10
TPOX
8,11
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.
Reddy J.K., Khanna P., Johnson J.T., Myers E.N., Gollin S.M.
Oral Oncol. 44:369-382(2008).
The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines.
Gollin S.M.
Oral Oncol. 43:701-712(2007).