UPCI-SCC-114Homo sapiens (Human)Cancer cell line

UPCI-SCC-114 is a human head and neck squamous cell carcinoma cell line that has been analyzed for TP53 mutations. The cell line was part of a study using peptide mass signature genotyping (PMSG) to detect mutations in TP53 exons 5-8 and 9. PMSG identified mutations in this cell line, demonstrating its utility in detecting minority mutations in tumor DNA. The cell line shows a combination of wild-type and mutant signatures, suggesting potential heterogeneity. This cell line is valuable for research on TP53 mutations and their implications in cancer progression and therapy response.