UPCI-SCC-116Homo sapiens (Human)Cancer cell line
Also known as: SCC116, UPCISCC116, UPCI:SCC116
🤖 AI SummaryBased on 2 publications
Quick Overview
Human head and neck squamous cell carcinoma cell line with TP53 mutations.
Detailed Summary
UPCI-SCC-116 is a human head and neck squamous cell carcinoma cell line that has been studied for TP53 mutations. It was identified as having mutations in exons 5 to 8 of the TP53 gene, which is a critical tumor suppressor gene. The cell line was part of a study that compared the effectiveness of different methods for detecting these mutations, including PMSG and dideoxy sequencing. The study found that PMSG was more reliable in detecting mutations in both tumor and cell-line DNA samples. Additionally, UPCI-SCC-116 was part of a study examining the ATR-CHEK1 pathway, which is involved in the response to DNA damage and may play a role in the resistance of some cancers to radiation therapy. The cell line showed upregulation of this pathway, suggesting potential implications for treatment strategies.
Research Applications
TP53 mutation detectionATR-CHEK1 pathway analysis
Key Characteristics
TP53 mutations in exons 5-8Upregulation of ATR-CHEK1 pathway
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2228 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, alveolar ridge[UBERON:UBERON_0004103] |
Donor Information
| Age | 57 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001698_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg175His (c.524G>A) | Unspecified | Somatic mutation acquired during proliferation | from parent cell line YCC-3 |
| MutationSimple | RHOA | p.Gly17Val (c.50G>T) | Unspecified | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,12
D13S317
9,11
D16S539
11,12
D18S51
14
D19S433
12,14
D21S11
30
D2S1338
20
D3S1358
15,16
D5S818
9,13
D7S820
8,12
D8S1179
13,14
FGA
20,21
Penta D
11
Penta E
7,10
TH01
9.3
TPOX
8,10
vWA
15,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas.
Vlad A., Gollin S.M.
Genes Chromosomes Cancer 53:25-37(2014).
The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines.
Gollin S.M.
Oral Oncol. 43:701-712(2007).