UPCI-SCC-131Homo sapiens (Human)Cancer cell line
Also known as: SCC131, UPCISCC131, UPCI:SCC131
🤖 AI SummaryBased on 2 publications
Quick Overview
Cisplatin-resistant oral squamous cell carcinoma cell line with stem-like and EMT features
Detailed Summary
UPCI-SCC-131 is a cisplatin-resistant oral squamous cell carcinoma (OSCC) cell line derived from a primary tumor. This cell line exhibits enhanced resistance to cisplatin through mechanisms involving upregulation of drug efflux pumps, cancer stem-cell-like properties, and epithelial-mesenchymal transition (EMT). The cell line shows increased expression of stem cell markers such as CD44 and c-Myc, as well as reduced E-cadherin, indicating EMT activation. miRNA profiling reveals a distinct signature associated with drug resistance, including upregulation of miR-130b, miR-134, miR-149, miR-491, miR-181d, and miR-146b. These features make UPCI-SCC-131 a valuable model for studying cisplatin resistance, cancer stem cells, and EMT in OSCC.
Research Applications
Cisplatin resistanceCancer stem cellsEpithelial-mesenchymal transition (EMT)miRNA profiling
Key Characteristics
Cisplatin resistanceUpregulated ABC-transporters (ABCB1, MRP1)Cancer stem-cell-like properties (CD44, c-Myc)EMT markers (reduced E-cadherin, increased BMI1, MMP9)Distinct miRNA signature (miR-130b, miR-134, miR-149, miR-491, miR-181d, miR-146b)
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2229 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, floor of mouth[UBERON:UBERON_0003679] |
Donor Information
| Age | 73 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001699_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12
D13S317
11,13
D16S539
13
D18S51
17,19
D19S433
13,15
D21S11
29,32.2
D2S1338
19,23
D3S1358
14
D5S818
11
D7S820
11,12
D8S1179
13
FGA
20,22
Penta D
11,13
Penta E
10
TH01
7,9
TPOX
8,11
vWA
15,17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
MicroRNA profiling of cisplatin-resistant oral squamous cell carcinoma cell lines enriched with cancer-stem-cell-like and epithelial-mesenchymal transition-type features.
Roychoudhury S.
Sci. Rep. 6:23932-23932(2016).
Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas.
Vlad A., Gollin S.M.
Genes Chromosomes Cancer 53:25-37(2014).