UPCI-SCC-154Homo sapiens (Human)Cancer cell line
Also known as: SCC154, UPCISCC154, UPCI:SCC154
🤖 AI SummaryBased on 5 publications
Quick Overview
Human head and neck squamous cell carcinoma cell line with HPV16 integration and p16 expression.
Detailed Summary
UPCI-SCC-154 is a human head and neck squamous cell carcinoma (HNSCC) cell line derived from a primary tumor. It is known for its HPV16 integration and p16 expression, which are significant in the context of oropharyngeal cancers. The cell line exhibits characteristics associated with HPV-positive tumors, including high p16 expression and specific genetic alterations. Research on UPCI-SCC-154 has contributed to understanding the molecular mechanisms of HPV-driven cancers and their response to therapies. The cell line is used in studies related to viral integration, gene expression, and radiosensitivity, providing insights into the biological behavior of HPV-positive HNSCC.
Research Applications
HPV integration analysisp16 expression studiesRadiosensitivity assaysGene expression profiling
Key Characteristics
HPV16 integrationp16 overexpressionHigh radiosensitivityGenomic alterations associated with HPV-positive tumors
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2230 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, tongue[UBERON:UBERON_0001723] |
Donor Information
| Age | 54 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral tongue |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001229_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,12
D13S317
9,12
D16S539
13
D18S51
15
D19S433
15.2,16
D21S11
28,29
D2S1338
25
D3S1358
15,16
D5S818
11,12
D7S820
9,10
D8S1179
12
FGA
20,24
Penta D
11,13
Penta E
5,14
TH01
7
TPOX
8,9
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Genotyping and characterization of HPV status, hypoxia, and radiosensitivity in 22 head and neck cancer cell lines.
Gottgens E.-L., Ansems M., Leenders W.P.J., Bussink J., Span P.N.
Cancers (Basel) 13:1069.1-1069.12(2021).
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Oncotarget 8:86369-86383(2017).
Spheroid-based 3D cell cultures enable personalized therapy testing and drug discovery in head and neck cancer.
Schwenk-Zieger S., Stauber R.H., Baumeister P., Becker S.
Anticancer Res. 37:2201-2210(2017).
Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.
Bier H., Brakenhoff R.H., Bradford C.R., Carey T.E.
Head Neck 39:840-852(2017).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma.
Doi K., Nakagawa K.
Cancer Med. 2:933-941(2013).