UPCI-SCC-172Homo sapiens (Human)Cancer cell line
Also known as: SCC172, UPCI:SCC172
🤖 AI SummaryBased on 2 publications
Quick Overview
Human head and neck squamous cell carcinoma cell line with TP53 mutations and ATR-CHEK1 pathway activation.
Detailed Summary
UPCI-SCC-172 is a human head and neck squamous cell carcinoma cell line that has been extensively studied for its genetic characteristics. This cell line exhibits TP53 mutations, which are common in head and neck cancers, and shows activation of the ATR-CHEK1 pathway, a key player in DNA damage response. The ATR-CHEK1 pathway upregulation in UPCI-SCC-172 contributes to its resistance to ionizing radiation, making it a valuable model for studying radioresistance mechanisms in cancer. Additionally, UPCI-SCC-172 has been used to investigate the role of chromosomal instability and genetic alterations in tumor progression and therapeutic response.
Research Applications
TP53 mutation analysisATR-CHEK1 pathway activation studiesRadioresistance mechanisms in cancerChromosomal instability and tumor progression
Key Characteristics
TP53 mutationsATR-CHEK1 pathway upregulationRadioresistanceChromosomal instability
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2231 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 68 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oropharynx |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oropharynx Squamous Cell Carcinoma |
| OncoTree Code | OPHSC |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001700_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Thr155Pro (c.463A>C) | Unspecified | - | PubMed=12872257 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
11
D16S539
10
D18S51
11
D19S433
13,15
D21S11
29,33.2
D2S1338
17,25
D3S1358
16,17
D5S818
12
D7S820
9,11
D8S1179
13
FGA
22,24
Penta D
13
Penta E
11,13
TH01
9.3
TPOX
11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas.
Vlad A., Gollin S.M.
Genes Chromosomes Cancer 53:25-37(2014).
The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines.
Gollin S.M.
Oral Oncol. 43:701-712(2007).