VCaPHomo sapiens (Human)Cancer cell line
Also known as: Vertebral Cancer of the Prostate, Vcap, VCAP
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_2235 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone, vertebra[UBERON:UBERON_0002412] |
Donor Information
| Age | 59 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Prostate carcinoma |
|---|---|
| Lineage | Prostate |
| Subtype | Prostate Adenocarcinoma |
| OncoTree Code | PRAD |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000115_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Trp (c.742C>T) | Homozygous | Somatic mutation acquired during proliferation | from parent cell line VCaP |
| MutationSimple | MLH1 | p.Ile219Val (c.655A>G) | Homozygous | - | from parent cell line VCaP |
| Gene fusion | ERG | TMPRSS2-ERG | - | - | from parent cell line VCaP |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Genomic characterization of preclinical prostate cancer cell line models.
Figg W.D. Sr.
Int. J. Mol. Sci. 25:6111.1-6111.19(2024).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Phenotypic characterization of two novel cell line models of castration-resistant prostate cancer.
Yegnasubramanian S.
Prostate 81:1159-1171(2021).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Nat. Commun. 10:3574.1-3574.11(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Genomic analysis of DNA repair genes and androgen signaling in prostate cancer.
Paschal B.M.
BMC Cancer 18:960.1-960.20(2018).
Paclitaxel resistance and the role of miRNAs in prostate cancer cell lines.
Sahin A., Balci F.
World J. Urol. 37:1117-1126(2019).
Serum-free complete medium, an alternative medium to mimic androgen deprivation in human prostate cancer cell line models.
Wu Y., Mohler J.L.
Prostate 78:213-221(2018).
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.
Gregory-Evans C.Y., Karnes R.J., Jenkins R.B., Klein E.A., Buttyan R.
Oncotarget 8:18949-18967(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A novel approach for characterizing microsatellite instability in cancer cells.
Lu Y.-H., Soong T.D., Elemento O.
PLoS ONE 8:E63056-E63056(2013).
Gene fusions by chromothripsis of chromosome 5q in the VCaP prostate cancer cell line.
Trapman J., Jenster G.
Hum. Genet. 132:709-713(2013).
Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer.
Yegnasubramanian S.
J. Pathol. 230:174-183(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines.
Rein A., De Marzo A.M.
PLoS ONE 6:E20874-E20874(2011).
Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines.
Nordeen S.K., Miller G.J., Varella-Garcia M.
Prostate 57:226-244(2003).
Molecular characterization of human prostate carcinoma cell lines.";
Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.
Prostate 57:205-225(2003).
VCaP, a cell-based model system of human prostate cancer.";
Vessella R.L., Lin D.L., Pienta K.J.
In Vivo 15:163-168(2001).