HLF-aHomo sapiens (Human)Undefined cell line type
Also known as: HLFA, HLFa
🤖 AI SummaryBased on 4 publications
Quick Overview
HLF-a is a human lung fibroblast cell line used in cancer research.
Detailed Summary
HLF-a is a human lung fibroblast cell line derived from the lung tissue. It is utilized in various cancer research studies, particularly in understanding the molecular mechanisms and drug sensitivity profiles of cancer cells. This cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and is used for genomic and pharmacological profiling to identify predictive biomarkers for anticancer drug sensitivity. The cell line's characteristics include its fibroblast origin and its application in studying the relationship between genetic variations and drug responses in cancer models.
Research Applications
Genomic and pharmacological profilingDrug sensitivity predictionMolecular mechanism studies
Key Characteristics
Fibroblast originPart of CCLEUsed for biomarker identification
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2255 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 54 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | black_or_african_american |
Disease Information
| Disease | Non-Cancerous |
|---|---|
| Lineage | Fibroblast |
| Subtype | Fibroblast, Soft Tissue |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000797_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
11,12
D16S539
12,13
D18S51
16,17
D19S433
14,14.2
D21S11
29,34
D2S1338
18,25
D3S1358
15
D5S818
8,12
D7S820
9,12
D8S1179
13,15
FGA
19
Penta D
7,11
Penta E
8,9
TH01
6,9.3
TPOX
6,8
vWA
15
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.
Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.
Br. J. Cancer 109:1599-1608(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Cultured cell lines for research on pulmonary physiology available through the American Type Culture Collection.
Hay R.J., Williams C.D., Macy M.L., Lavappa K.S.
Am. Rev. Respir. Dis. 125:222-232(1982).
Fibroblasts cell lines misclassified as cancer cell lines.";
de Weck A., Bitter H., Kauffmann A.
bioRxiv 2017:166199-166199(2017).