1156QE/8Homo sapiens (Human)Cancer cell line
Also known as: 1156Q, 11156-Q-E, 1156QE
🤖 AI SummaryBased on 2 publications
Quick Overview
Human testicular teratocarcinoma cell line with embryonal carcinoma features.
Detailed Summary
The 1156QE/8 cell line is derived from human testicular teratocarcinoma and exhibits characteristics of embryonal carcinoma. It was studied in a comparative analysis of eight cell lines, showing morphological and functional similarities to murine embryonal carcinoma (EC) cells. The line demonstrates variable expression of cell surface antigens, including low levels of HLA and β2-microglobulin, and weak SSEA-1 expression. It produces low levels of chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP), suggesting limited differentiation. The cell line was found to form tumors in immunosuppressed mice, resembling human embryonal carcinoma histologically. Copy number analysis using oligonucleotide microarrays confirmed genomic alterations, including amplifications and deletions, consistent with cancer-related changes. These properties make 1156QE/8 a valuable model for studying human testicular germ-cell tumors and their differentiation potential.
Research Applications
Comparative study of human testicular germ-cell tumorsAnalysis of embryonal carcinoma differentiationGenomic copy number variation studies
Key Characteristics
Morphological similarity to murine embryonal carcinoma cellsVariable cell surface antigen expressionTumor formation in immunosuppressed miceCopy number alterations consistent with cancer
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2262 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 22 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Embryonal carcinoma |
|---|---|
| Lineage | Testis |
| Subtype | Embryonal Carcinoma |
| OncoTree Code | EMBCA |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001435_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
8,9
D16S539
11,14
D5S818
11,12
D7S820
9
TH01
9.3
TPOX
8
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
High-resolution analysis of DNA copy number using oligonucleotide microarrays.
Weber B., Shapero M.H., Wooster R.
Genome Res. 14:287-295(2004).
Nonrandom abnormalities in chromosome 1 in human testicular cancers.
Wang N., Trend B., Bronson D.L., Fraley E.E.
Cancer Res. 40:796-802(1980).