1777N RpmetHomo sapiens (Human)Cancer cell line

The 1777N Rpmet cell line is a human embryonal carcinoma cell line derived from testicular germ cell tumors. It exhibits differentiation potential when cultured at low density, showing changes in cell morphology and secretion of hCG and AFP. The cells require feeder layers for efficient attachment and maintenance of differentiation potential. Studies indicate that these cells undergo irreversible changes in morphology and growth rate when cultured without feeder layers, and their differentiation capacity diminishes with high-density passages. The 1777N Rpmet line is part of a group of three pluripotential EC lines, with some clonal derivatives showing extensive differentiation when seeded at low density.