833K-EHomo sapiens (Human)Cancer cell line
Also known as: HT-E, 833K, 833-KE, 833KE, 833K-2
🤖 AI SummaryBased on 5 publications
Quick Overview
Human testicular germ cell tumor cell line with chromosomal abnormalities
Detailed Summary
The 833K-E cell line is a human testicular germ cell tumor-derived cell line characterized by specific chromosomal abnormalities, including rearrangements on chromosome 12p. It has been used in studies investigating the genetic changes associated with testicular germ cell tumors, particularly focusing on the 12p region. This cell line has been utilized to study the molecular mechanisms underlying tumor development and drug resistance, especially in the context of cisplatin resistance. The cell line has also been analyzed for its potential as a model for understanding the genetic instability and chromosomal alterations observed in human testicular germ cell tumors. Research involving 833K-E has contributed to the understanding of the role of specific chromosomal regions in tumor progression and has been used in comparative studies with other cell lines to identify unique genetic features.
Research Applications
Chromosomal rearrangement analysisDrug resistance studiesGenetic instability investigationTesticular germ cell tumor modeling
Key Characteristics
Chromosomal abnormalities on 12pCisplatin-resistant subcloneGenetic instabilityTesticular germ cell tumor origin
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2292 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Abdomen[UBERON:UBERON_0000916] |
Donor Information
| Age | 19 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Non-central nervous system-localized embryonal carcinoma |
|---|---|
| Lineage | Testis |
| Subtype | Embryonal Carcinoma |
| OncoTree Code | EMBCA |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001440_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
D18S51
12,16
D21S11
28,31
D8S1179
13
FGA
22
TH01
6,9
vWA
15,18,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
High-resolution analysis of DNA copy number using oligonucleotide microarrays.
Weber B., Shapero M.H., Wooster R.
Genome Res. 14:287-295(2004).
Short tandem repeat profiling provides an international reference standard for human cell lines.
Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
Characterization of multiple 12p rearrangements in testicular germ cell tumor cell line 833K and its subclone 64CP by chromosome microdissection.
Heerema N.A.
Cancer Genet. Cytogenet. 106:24-29(1998).
Nonrandom abnormalities in chromosome 1 in human testicular cancers.
Wang N., Trend B., Bronson D.L., Fraley E.E.
Cancer Res. 40:796-802(1980).
Cell line derived from a metastasis of a human testicular germ cell tumor.
Fraley E.E.
Cancer Res. 40:2500-2506(1980).
A comparative study of eight cell lines derived from human testicular teratocarcinoma.
Andrews P.W., Bronson D.L., Benham F.J., Strickland S., Knowles B.B.
Int. J. Cancer 26:269-280(1980).