ANGM-CSSHomo sapiens (Human)Cancer cell line
Also known as: ANGMCSS
🤖 AI SummaryBased on 1 publications
Quick Overview
Human glioblastoma cell line for cancer research.
Detailed Summary
ANGM-CSS is a human glioblastoma multiforme cell line established from a 56-year-old male patient. The cell line exhibits a near-tetraploid karyotype with multiple chromosomal abnormalities, including amplifications of MET and EGFR genes, and deletions of NF1, CDKN2A, and CDKN2B. It shows tumorigenicity in immunodeficient mice, making it a valuable model for studying glioblastoma molecular pathology and evaluating novel therapeutic drugs. Immunophenotyping reveals expression of CD133, nestin, and vimentin, with variable GFAP positivity. The cell line does not exhibit MGMT promoter methylation or mutations in TP53 or KRAS genes.
Research Applications
Cancer researchMolecular pathology of glioblastomaTherapeutic drug testing
Key Characteristics
Near-tetraploid karyotypeAmplification of MET and EGFR genesDeletion of NF1, CDKN2A, and CDKN2BTumorigenic in immunodeficient miceExpression of CD133, nestin, and vimentinNo MGMT promoter methylationNo TP53 or KRAS mutations
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2297 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain, left temporo-occipital lobe |
Donor Information
| Age | 65 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Glioblastoma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Glioblastoma |
| OncoTree Code | GB |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001329_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,12
D13S317
8
D16S539
11,12
D18S51
12,17
D21S11
30,31.2
D3S1358
16,17
D5S818
11
D7S820
10,11
D8S1179
13,16
FGA
21
Penta D
10,13
Penta E
7,10
TH01
6,9
TPOX
11
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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