BICR 16Homo sapiens (Human)Cancer cell line

Also known as: Beatson Institute for Cancer Research 16, BICR-16 R, BICR16, BICR-16

🤖 AI SummaryBased on 6 publications

Quick Overview

Human squamous cell carcinoma cell line with p53 mutations and genetic instability.

Detailed Summary

BICR 16 is a human squamous cell carcinoma cell line derived from head and neck tumors. It exhibits p53 mutations and genetic instability, as indicated by the presence of multiple mutations and loss of heterozygosity. The cell line shows resistance to apoptosis and has been used in studies examining the role of p53 in tumor progression and drug sensitivity. BICR 16 is part of a series of cell lines that have been characterized for their genetic alterations and their implications in cancer biology. These cell lines are valuable for studying the molecular mechanisms underlying squamous cell carcinoma development and for testing therapeutic strategies.

Research Applications

Study of p53 mutations in tumor progressionInvestigation of genetic instability in cancerDrug sensitivity testingMolecular mechanisms of squamous cell carcinoma

Key Characteristics

p53 mutationsGenetic instabilityResistance to apoptosisLoss of heterozygosity

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2308
Species	Homo sapiens (Human)
Tissue Source	Oral cavity, tongue[UBERON:UBERON_0001723]

Donor Information

Age Category	Unknown
Sex	Male
Race	caucasian

Disease Information

Disease	Squamous cell carcinoma of the oral tongue
Lineage	Head and Neck
Subtype	Oral Cavity Squamous Cell Carcinoma
OncoTree Code	OCSC

DepMap Information

Source Type	ECACC
Source ID	ACH-000503_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Trp146Ter (c.438G>A)	Unspecified	-	CelloPub=CLPUB00546

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

D5S818

D7S820

TH01

6,9

TPOX

8,11

vWA

17,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

Keith W.N., Frame M.C.

Oncogene 18:5646-5653(1999).

DOI PubMed

Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.

Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.

Br. J. Cancer 67:1274-1284(1993).

DOI PubMed PMC

Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

Edington K.G., Loughran O.P., Berry I.J., Parkinson E.K.

Mol. Carcinog. 13:254-265(1995).

DOI PubMed