BICR 22Homo sapiens (Human)Cancer cell line

Also known as: Beatson Institute for Cancer Research 22, BICR-22 M, BICR22, BICR-22

🤖 AI SummaryBased on 9 publications

Quick Overview

Human squamous cell carcinoma cell line with p53 mutations and immortal characteristics.

Detailed Summary

BICR 22 is a human squamous cell carcinoma cell line derived from head and neck squamous cell carcinoma (SCC-HN). It exhibits immortal characteristics, with evidence of p53 mutations and high levels of p53 protein expression. The cell line shows resistance to suspension-induced death and has a prolonged proliferative life span. BICR 22 is associated with metastatic disease and has been used in studies investigating the genetic alterations linked to tumor progression, including loss of heterozygosity (LOH) at specific chromosomal loci. Research on BICR 22 has contributed to understanding the role of p53 dysfunction and other genetic changes in the development of SCC-HN.

Research Applications

Cancer researchGenetic mutation analysisImmortalization studiesTumor progression analysis

Key Characteristics

Immortalp53 mutationsHigh p53 protein expressionMetastatic origin
Generated on 6/18/2025

Basic Information

Database IDCVCL_2310
SpeciesHomo sapiens (Human)
Tissue SourceLymph node[UBERON:UBERON_0000029]

Donor Information

Age88
Age CategoryAdult
SexMale
Racecaucasian

Disease Information

DiseaseSquamous cell carcinoma of the oral tongue
LineageHead and Neck
SubtypeOral Cavity Squamous Cell Carcinoma
OncoTree CodeOCSC

DepMap Information

Source TypeECACC
Source IDACH-000794_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53c.920-1G>T (IVS8-1G>T)HeterozygousSplice acceptor mutationUnknown, PubMed=25275298

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11
D13S317
11,13
D16S539
11,12
D18S51
14
D21S11
28,31
D3S1358
15
D5S818
11,12
D7S820
11,12
D8S1179
10,15
FGA
23,24
Penta D
9,13
Penta E
12,14
TH01
6,7
TPOX
8
vWA
16,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.

Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.

Oncotarget 5:8906-8923(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.

Parkinson E.K.

Oncogene 14:1955-1964(1997).

Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.

Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.

Br. J. Cancer 67:1274-1284(1993).

Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

Edington K.G., Loughran O.P., Berry I.J., Parkinson E.K.

Mol. Carcinog. 13:254-265(1995).