BICR 3Homo sapiens (Human)Cancer cell line
Also known as: Beatson Institute for Cancer Research 3, BICR3, BICR-3
🤖 AI SummaryBased on 4 publications
Quick Overview
Human squamous cell carcinoma cell line with p53 mutations and immortal characteristics.
Detailed Summary
BICR 3 is a human squamous cell carcinoma cell line derived from head and neck squamous cell carcinoma (SCC-HN). It exhibits immortal characteristics, with a high proliferative capacity in vitro. The cell line shows p53 mutations, including a codon 282 mutation (CGG-CCG, arg-pro), and is associated with loss of heterozygosity (LOH) at multiple chromosomal loci, including 3p21.2-p21.3 and 4q32-q34. BICR 3 demonstrates elevated levels of p53 protein and is part of a series of cell lines used to study the genetic alterations linked to SCC-HN progression. It is also noted for its ability to form colonies in culture and its association with advanced tumor stages, indicating its relevance in understanding the molecular mechanisms of cancer immortality and progression.
Research Applications
Study of p53 mutations in squamous cell carcinomaAnalysis of loss of heterozygosity (LOH) in cancer progressionInvestigation of immortalization mechanisms in SCC-HNCharacterization of genetic alterations associated with cancer
Key Characteristics
Immortal phenotypep53 mutationsLoss of heterozygosity at multiple lociElevated p53 protein levels
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2311 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, alveolar ridge[UBERON:UBERON_0004103] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001445_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg282Pro (c.845G>C) | Homozygous | - | PubMed=29970484, PubMed=8725545 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
8,13
D16S539
11
D5S818
11,12
D7S820
10,13
TH01
6,7
TPOX
8
vWA
14,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.
Keith W.N., Frame M.C.
Oncogene 18:5646-5653(1999).
Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.
Parkinson E.K.
Oncogene 14:1955-1964(1997).
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.
Br. J. Cancer 67:1274-1284(1993).