BICR 31Homo sapiens (Human)Cancer cell line

Also known as: Beatson Institute for Cancer Research 31, BICR31, BICR-31

🤖 AI SummaryBased on 9 publications

Quick Overview

Human squamous cell carcinoma cell line with p53 mutations and immortal characteristics.

Detailed Summary

BICR 31 is a human squamous cell carcinoma (SCC) cell line derived from head and neck tumors. It exhibits immortal characteristics, with a high proliferative capacity in vitro. The cell line is associated with p53 mutations, which are frequently observed in SCCs and contribute to the loss of cell cycle regulation. BICR 31 shows resistance to apoptosis and has been used in studies investigating the role of p53 dysfunction in tumor progression. Additionally, it has been implicated in research on the genetic alterations linked to cellular immortality and the development of head and neck cancers. The cell line is also noted for its ability to form tumors in vivo, making it a valuable model for studying cancer biology and therapeutic responses.

Research Applications

Cancer biologyTumor progressionp53 mutation studiesImmortalization mechanismsDrug response profiling

Key Characteristics

Immortalp53 mutationsResistance to apoptosisTumorigenic in vivo

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2312
Species	Homo sapiens (Human)
Tissue Source	Oral cavity, tongue[UBERON:UBERON_0001723]

Donor Information

Age Category	Unknown
Sex	Male
Race	caucasian

Disease Information

Disease	Squamous cell carcinoma of the oral tongue
Lineage	Head and Neck
Subtype	Oral Cavity Squamous Cell Carcinoma
OncoTree Code	OCSC

DepMap Information

Source Type	ECACC
Source ID	ACH-000228_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Val173_Arg174InsGly (c.518_520delTGA)	Homozygous	-	Unknown, Unknown, PubMed=8390283

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

9,14

D13S317

D16S539

11,12

D18S51

D21S11

D3S1358

D5S818

D7S820

8,12

D8S1179

FGA

Penta D

Penta E

TH01

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

Keith W.N., Frame M.C.

Oncogene 18:5646-5653(1999).

DOI PubMed

Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.

Parkinson E.K.

Oncogene 14:1955-1964(1997).

DOI PubMed

Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.

Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.

Br. J. Cancer 67:1274-1284(1993).

DOI PubMed PMC

Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

Edington K.G., Loughran O.P., Berry I.J., Parkinson E.K.

Mol. Carcinog. 13:254-265(1995).

DOI PubMed