BICR 6Homo sapiens (Human)Cancer cell line

Also known as: Beatson Institute for Cancer Research 6, BICR6, BICR-6

🤖 AI SummaryBased on 7 publications

Quick Overview

Human squamous cell carcinoma cell line with p53 mutations and immortal characteristics.

Detailed Summary

BICR 6 is a human squamous cell carcinoma cell line derived from head and neck squamous cell carcinoma (SCC-HN). It exhibits immortal characteristics, with a high proliferative capacity in vitro. The cell line is associated with p53 mutations, which are common in many human cancers. BICR 6 shows resistance to suspension-induced death and has a prolonged proliferative life span. It is used in studies related to cancer immortality, p53 function, and tumor progression. The cell line has been utilized in research on genetic alterations, including loss of heterozygosity (LOH) at specific chromosomal loci, and its role in cancer development and treatment response.

Research Applications

Cancer immortalityp53 mutation analysisTumor progression studiesGenetic alterations and LOH analysis

Key Characteristics

Immortalp53 mutationsResistance to suspension-induced deathProlonged proliferative life span

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2314
Species	Homo sapiens (Human)
Tissue Source	Pharynx, hypopharynx[UBERON:UBERON_0001051]

Donor Information

Age Category	Unknown
Sex	Male
Race	caucasian

Disease Information

Disease	Squamous cell carcinoma of the hypopharynx
Lineage	Head and Neck
Subtype	Hypopharynx Squamous Cell Carcinoma
OncoTree Code	HPHSC

DepMap Information

Source Type	ECACC
Source ID	ACH-000415_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gln192Ter (c.574C>T)	Unspecified	-	PubMed=28273451, PubMed=22931248

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

D5S818

D7S820

TH01

TPOX

9,11

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

Keith W.N., Frame M.C.

Oncogene 18:5646-5653(1999).

DOI PubMed

Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.

Parkinson E.K.

Oncogene 14:1955-1964(1997).

DOI PubMed

Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.

Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.

Br. J. Cancer 67:1274-1284(1993).

DOI PubMed PMC

Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

Edington K.G., Loughran O.P., Berry I.J., Parkinson E.K.

Mol. Carcinog. 13:254-265(1995).

DOI PubMed