BICR 78Homo sapiens (Human)Cancer cell line

Also known as: Beatson Institute for Cancer Research 78, BICR78, BICR-78

🤖 AI SummaryBased on 8 publications

Quick Overview

Human squamous cell carcinoma cell line with p53 mutations and chromosomal abnormalities.

Detailed Summary

BICR 78 is a human squamous cell carcinoma cell line derived from head and neck tumors. It exhibits p53 mutations and chromosomal abnormalities, including loss of heterozygosity (LOH) at multiple loci. This cell line is used in research to study the genetic alterations associated with cancer progression and immortality. BICR 78 shows characteristics of immortalized cells, such as indefinite proliferation in vitro, and is part of a panel of cell lines used to investigate the molecular mechanisms of cancer development and therapeutic responses.

Research Applications

Study of genetic alterations in cancer progressionInvestigation of p53 mutations and their role in tumorigenesisAnalysis of chromosomal abnormalities and LOH in cancer cellsResearch on immortalization mechanisms in cancer cells

Key Characteristics

p53 mutationsChromosomal abnormalitiesLoss of heterozygosity at multiple lociImmortalized cell line with indefinite proliferation

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2315
Species	Homo sapiens (Human)
Tissue Source	Oral cavity, alveolar ridge[UBERON:UBERON_0004103]

Donor Information

Age Category	Unknown
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the oral cavity
Lineage	Head and Neck
Subtype	Oral Cavity Squamous Cell Carcinoma
OncoTree Code	OCSC

DepMap Information

Source Type	Sigma-Aldrich
Source ID	ACH-001332_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Pro177Leu (c.530C>T)	Unspecified	-	PubMed=8412323, PubMed=7727782
MutationSimple	TP53	p.Cys176Phe (c.527G>T)	Unspecified	-	PubMed=8221663
MutationSimple	TP53	p.Gln38Ter (c.112C>T)	Heterozygous	-	Unknown, Unknown
MutationUnexplicit	PARD3	Ex3-7del	Homozygous	-	PubMed=20215515

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

11,12

D18S51

13,19

D21S11

33.2

D3S1358

D5S818

D7S820

10,11

D8S1179

FGA

Penta D

Penta E

11,13

TH01

6,9.3

TPOX

9,10

vWA

15,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

Keith W.N., Frame M.C.

Oncogene 18:5646-5653(1999).

DOI PubMed

Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.

Parkinson E.K.

Oncogene 14:1955-1964(1997).

DOI PubMed

Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

Edington K.G., Loughran O.P., Berry I.J., Parkinson E.K.

Mol. Carcinog. 13:254-265(1995).

DOI PubMed