COLO 794Homo sapiens (Human)Cancer cell line
Also known as: Colorado 794, COLO794, COLO #794, Colo 794, COLO-794
🤖 AI SummaryBased on 3 publications
Quick Overview
Human melanoma cell line with HLA homozygosity and potential for immunotherapy research.
Detailed Summary
COLO 794 is a human melanoma cell line derived from a primary tumor. It exhibits high frequency of HLA class I and II homozygosity, which may contribute to immune evasion mechanisms. The cell line shows loss of heterozygosity on chromosome 6, particularly in the HLA region, which is associated with immune escape in melanoma. COLO 794 has been characterized for its HLA genotype and expression, revealing a pattern of homozygosity that may impact antigen presentation and immune recognition. This cell line is valuable for studying HLA-related immune responses and cancer immunotherapy strategies.
Research Applications
Immunotherapy researchHLA-related immune responsesCancer cell line modeling
Key Characteristics
HLA class I and II homozygosityLoss of heterozygosity on chromosome 6Potential for immune evasion
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2408 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 14 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
Disease Information
| Disease | Cutaneous melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Cutaneous Melanoma |
| OncoTree Code | SKCM |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001339_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Cys135Arg (c.403T>C) | Heterozygous | - | Unknown |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10
D13S317
11,13
D16S539
11
D18S51
13,14
D21S11
29,30
D3S1358
18
D5S818
11
D7S820
10,11
D8S1179
14,15
FGA
23
Penta D
11,13
Penta E
7
TH01
6
TPOX
11
vWA
16,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).