COR-L24Homo sapiens (Human)Cancer cell line
Also known as: CORL24, Cor L24, COR L24
🤖 AI SummaryBased on 6 publications
Quick Overview
Human small cell lung cancer cell line with known genetic and chromosomal abnormalities.
Detailed Summary
COR-L24 is a human small cell lung cancer (SCLC) cell line established from a patient with lung cancer. It is characterized by specific genetic and chromosomal abnormalities, including deletions on chromosome 3p and amplifications of myc genes. The cell line exhibits resistance to glucocorticoid inhibition, which is a notable feature in SCLC research. COR-L24 is used in studies related to cancer genetics, drug sensitivity, and molecular mechanisms of tumor progression. It is part of a panel of cell lines that have been extensively analyzed for their molecular profiles and are utilized in research to understand the biological and therapeutic implications of SCLC. The cell line has been used in studies involving chromosomal abnormalities, oncogene amplification, and the role of glucocorticoids in regulating ACTH precursor peptides.
Research Applications
Cancer geneticsDrug sensitivity profilingMolecular mechanisms of tumor progressionChromosomal abnormalities in cancerOncogene amplificationGlucocorticoid resistance in SCLC
Key Characteristics
Amplification of myc genesDeletion on chromosome 3pResistance to glucocorticoid inhibitionExpression of ACTH precursor peptides
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2409 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age | 71 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Small cell lung cancer |
|---|---|
| Lineage | Lung |
| Subtype | Small Cell Lung Cancer |
| OncoTree Code | SCLC |
DepMap Information
| Source Type | ECACC |
|---|---|
| Source ID | ACH-000382_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Tyr234Cys (c.701A>G) | Heterozygous | - | PubMed=27822414 |
| MutationSimple | APC | p.Glu1554Ter (c.4660G>T) | Unspecified | - | PubMed=28179481 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
12
D16S539
12
D5S818
11
D7S820
11
TH01
7,9.3
TPOX
8
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Chromosomal alterations in small cell lung cancer revealed by multicolour fluorescence in situ hybridization.
Cawkwell L.
Int. J. Cancer 102:230-236(2002).
Glucocorticoid inhibition of ACTH peptides: small cell lung cancer cell lines are more resistant than pituitary corticotroph adenoma cells.
White A.
J. Mol. Endocrinol. 10:25-32(1993).
Oncogene amplification and chromosomal abnormalities in small cell lung cancer.
Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H.
J. Cell. Biochem. 33:267-288(1987).