COR-L311Homo sapiens (Human)Cancer cell line
Also known as: CORL311
🤖 AI SummaryBased on 2 publications
Quick Overview
Human cell line for cancer research and drug sensitivity studies.
Detailed Summary
COR-L311 is a human cell line utilized in cancer research, particularly in studies focused on drug sensitivity and anticancer drug response. It is part of the Cancer Cell Line Encyclopedia (CCLE), which provides comprehensive genomic and pharmacological data for a wide range of cancer cell lines. The CCLE aims to identify genetic, lineage, and gene-expression-based predictors of drug sensitivity, enabling the development of personalized therapeutic regimens. COR-L311's inclusion in this extensive dataset allows researchers to explore its genomic and pharmacological profiles in the context of various cancer types and treatment strategies.
Research Applications
Cancer researchDrug sensitivity studiesAnticancer drug response profiling
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Used for genomic and pharmacological profilingPotential for personalized therapeutic regimen development
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2412 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 63 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Small cell lung cancer |
|---|---|
| Lineage | Lung |
| Subtype | Small Cell Lung Cancer |
| OncoTree Code | SCLC |
DepMap Information
| Source Type | ECACC |
|---|---|
| Source ID | ACH-000187_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | c.920-1G>A (IVS8-1G>A) | Homozygous | Splice acceptor mutation | Unknown, Unknown |
| MutationSimple | RB1 | p.Ser82Ter (c.245C>A) | Homozygous | - | from parent cell line Lu-65 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
12
D16S539
11,12
D5S818
14
D7S820
8,10
TH01
6,9.3
TPOX
8
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).