COR-L47Homo sapiens (Human)Cancer cell line

Also known as: CORL47, Cor L47

🤖 AI SummaryBased on 8 publications

Quick Overview

Human small cell lung cancer cell line with known genetic and molecular characteristics.

Detailed Summary

COR-L47 is a human small cell lung cancer (SCLC) cell line established from a bone marrow aspirate. It is characterized by specific genetic alterations, including amplification of the c-myc gene and deletions in chromosome 3. The cell line exhibits distinct morphological and biochemical features, such as low expression of neuroendocrine markers and variable levels of L-dopa decarboxylase. COR-L47 has been used in studies investigating the molecular mechanisms of SCLC, including the role of oncogenes and chromosomal abnormalities in tumor progression. It is also utilized in research on drug sensitivity and resistance, contributing to the understanding of therapeutic strategies for SCLC. The cell line's genetic profile and behavior make it a valuable model for studying the biology of small cell lung cancer.

Research Applications

Molecular mechanisms of SCLCOncogene amplification studiesChromosomal abnormalities in cancerDrug sensitivity and resistanceTumor biology and progression

Key Characteristics

Amplification of c-mycDeletion in chromosome 3Variable L-dopa decarboxylase expressionLow neuroendocrine marker expression

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2415
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	67
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ECACC
Source ID	ACH-000695_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg306Ter (c.916C>T)	Heterozygous	Germline	PubMed=16418264
MutationSimple	PTEN	p.Glu18Ter (c.52G>T)	Homozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

D16S539

11,12

D18S51

13,15

D21S11

30,31.2

D3S1358

D5S818

10,13

D7S820

8,10

D8S1179

12,14

FGA

Penta D

9,12

Penta E

11,12

TH01

6,8

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Chromosomal alterations in small cell lung cancer revealed by multicolour fluorescence in situ hybridization.

Cawkwell L.

Int. J. Cancer 102:230-236(2002).

DOI PubMed

Oncogene amplification and chromosomal abnormalities in small cell lung cancer.

Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H.

J. Cell. Biochem. 33:267-288(1987).

DOI PubMed

Establishment and characterisation of cell lines from patients with lung cancer (predominantly small cell carcinoma).

Watson J.V., Johnson N., Reeve J.G., Bleehen N.M.

Br. J. Cancer 52:495-504(1985).

DOI PubMed PMC