COR-L95Homo sapiens (Human)Cancer cell line
Also known as: CORL95
🤖 AI SummaryBased on 4 publications
Quick Overview
Human cancer cell line for research on cancer biology and drug sensitivity.
Detailed Summary
COR-L95 is a human cancer cell line used in research to study cancer biology and drug sensitivity. It is part of the Cancer Cell Line Encyclopedia (CCLE), which provides genomic and pharmacological data for 947 human cancer cell lines. The CCLE aims to identify genetic, lineage, and gene-expression-based predictors of drug sensitivity, aiding in the development of personalized cancer treatments. COR-L95's data is utilized in studies involving large-scale genomic profiling and pharmacological screening to understand cancer mechanisms and improve therapeutic strategies.
Research Applications
Cancer biology researchDrug sensitivity profilingGenomic and pharmacological data analysis
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Used for large-scale genomic and pharmacological studies
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2418 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 64 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Small cell lung cancer |
|---|---|
| Lineage | Lung |
| Subtype | Small Cell Lung Cancer |
| OncoTree Code | SCLC |
DepMap Information
| Source Type | ECACC |
|---|---|
| Source ID | ACH-000743_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Asp259Tyr (c.775G>T) | Unspecified | - | PubMed=25010205 |
| MutationSimple | RB1 | c.265-1G>A | Homozygous | Splice acceptor mutation | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11
D13S317
8,11
D16S539
11,13
D5S818
13
D7S820
10
TH01
6
TPOX
9,10
vWA
16,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).