COV413AHomo sapiens (Human)Cancer cell line
Also known as: COV 413A
🤖 AI SummaryBased on 4 publications
Quick Overview
Human ovarian carcinoma cell line for cancer research.
Detailed Summary
COV413A is a human ovarian carcinoma cell line established from a patient with varying histology of the primary tumor. It is part of a panel of 8 neoplastic cell lines derived from 7 patients with ovarian tumors of different histological types. COV413A exhibits stable growth characteristics and has been used in studies involving genetic and immunological analyses. The cell line has been characterized for its DNA index, cytogenetic abnormalities, and growth features, making it a valuable model for studying ovarian cancer biology and drug sensitivity. COV413A is also part of a comprehensive database integrating HLA type, predicted neo-epitopes, virus, and gene expression, enhancing its utility in cancer research.
Research Applications
Cancer biologyDrug sensitivity testingGenetic and immunological analysis
Key Characteristics
Stable growth in cultureDNA index analysisCytogenetic abnormalitiesHLA type and expression data
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2422 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Colon, sigmoid[UBERON:UBERON_0001159] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
Disease Information
| Disease | Ovarian carcinoma |
|---|---|
| Lineage | Ovary/Fallopian Tube |
| Subtype | Serous Ovarian Cancer |
| OncoTree Code | SOC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001340_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg342Ter (c.1024C>T) | Homozygous | - | PubMed=29970484 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
12
D16S539
11
D18S51
18
D19S433
14,15
D21S11
31.2
D2S1338
17
D3S1358
14
D5S818
9,12
D7S820
8,13
D8S1179
13,14
FGA
19
Penta D
14
Penta E
12,14
TH01
6
TPOX
9
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
Helleman J.
PLoS ONE 9:E103988-E103988(2014).
Transcription of the gene encoding melanoma-associated antigen gp100 in tissues and cell lines other than those of the melanocytic lineage.
van der Spek C.W., Adema G.J., Schrier P.I., Figdor C.G.
Br. J. Cancer 76:1562-1566(1997).