COV504Homo sapiens (Human)Cancer cell line

Also known as: COV 504, Cov504

🤖 AI SummaryBased on 8 publications

Quick Overview

COV504 is a human ovarian cancer cell line derived from a serous carcinoma, used in cancer research.

Detailed Summary

COV504 is a human ovarian cancer cell line derived from a serous carcinoma, commonly used in cancer research. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for genomic and transcriptomic profiles. COV504 exhibits specific genetic and molecular characteristics that make it a valuable model for studying high-grade serous ovarian cancer (HGSOC). Research on COV504 has contributed to understanding the genomic similarities between cell lines and primary tumors, highlighting its utility in preclinical studies. The cell line has been utilized in studies examining drug sensitivity, gene expression, and molecular profiling, providing insights into cancer biology and therapeutic strategies.

Research Applications

Genomic profilingTranscriptomic analysisDrug sensitivity testingMolecular profiling

Key Characteristics

High-grade serous ovarian cancer modelPart of the Cancer Cell Line Encyclopedia (CCLE)Used in studies on genomic and transcriptomic profilesRelevant for preclinical cancer research

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2424
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age Category	Unknown
Sex	Female

Disease Information

Disease	Ovarian carcinoma
Lineage	Ovary/Fallopian Tube
Subtype	Serous Ovarian Cancer
OncoTree Code	SOC

DepMap Information

Source Type	ECACC
Source ID	ACH-001048_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Leu323fs (c.966_967delAC)	Unspecified	-	Unknown, PubMed=28273451, PubMed=25230021

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

12,13

D13S317

9,11

D16S539

9,11

D18S51

D19S433

D21S11

D2S1338

17,19

D3S1358

D5S818

D7S820

10,12

D8S1179

12,13

FGA

Penta D

Penta E

7,16

TH01

6,7

TPOX

8,9

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.

Drapkin R.I., Ailles L., Mes-Masson A.-M., Rottapel R.

Cell Rep. 18:2343-2358(2017).

DOI PubMed

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.

Helleman J.

PLoS ONE 9:E103988-E103988(2014).

DOI PubMed PMC

Evaluating cell lines as tumour models by comparison of genomic profiles.

Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.

Nat. Commun. 4:2126.1-2126.10(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: growth features and cytogenetics.

Cornelisse C.J., Schrier P.I.

Int. J. Cancer 53:613-620(1993).

DOI PubMed