FTC-238Homo sapiens (Human)Cancer cell line

Also known as: FTC238, CFT-238 (In the French and Spanish abstracts where the abbreviation 'FTC' was translated to 'CFT' and thus also the cell line names.)

🤖 AI SummaryBased on 5 publications

Quick Overview

Human follicular thyroid cancer cell line with metastatic potential.

Detailed Summary

FTC-238 is a human follicular thyroid cancer cell line derived from a patient's lung metastasis. It exhibits high invasive potential in vitro, characterized by increased β1 integrin expression and protease activity. This cell line is used to study the mechanisms of cancer invasion and metastasis, particularly in relation to integrin-mediated adhesion and proteolytic degradation of the extracellular matrix. FTC-238 shows distinct differences in invasiveness compared to non-metastatic clones, making it a valuable model for understanding the progression of thyroid cancer.

Research Applications

Cancer invasion and metastasisIntegrin-mediated adhesionProtease activity in tumor progression

Key Characteristics

High in vitro invasivenessIncreased β1 integrin expressionActive protease production

Generated on 6/18/2025

Basic Information

Database ID	CVCL_2447
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	42
Age Category	Adult
Sex	Male

Disease Information

Disease	Differentiated thyroid carcinoma
Lineage	Thyroid
Subtype	Follicular Thyroid Cancer
OncoTree Code	THFO

DepMap Information

Source Type	ECACC
Source ID	ACH-000897_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273His (c.818G>A)	Homozygous	-	Unknown, PubMed=16264262
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	RB1	p.Arg320Ter (c.958C>T)	Heterozygous	-	PubMed=25326674
MutationSimple	PTEN	p.Arg130Ter (c.388C>T)	Homozygous	-	Unknown, Unknown
MutationSimple	MSH6	p.Lys1045fs (c.3135delG)	Homozygous	-	PubMed=30737244

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11

D13S317

D16S539

11,12

D18S51

11,12

D19S433

D21S11

32.2

D2S1338

D3S1358

D5S818

11,12

D7S820

9,10

D8S1179

FGA

Penta D

Penta E

TH01

9.3

TPOX

vWA

15,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.

Fagin J.A., Schweppe R.E.

Clin. Cancer Res. 25:3141-3151(2019).

DOI PubMed PMC

ROS-induced near-homozygous genomes in thyroid cancer.";

van Wezel T., Morreau H.

Endocr. Relat. Cancer 25:83-97(2018).

DOI PubMed

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

p73 tumor-suppressor activity is impaired in human thyroid cancer.";

Vigneri P.

Cancer Res. 63:5829-5837(2003).

PubMed

Invasion by cultured human follicular thyroid cancer correlates with increased beta 1 integrins and production of proteases.

Clark O.H.

World J. Surg. 16:770-776(1992).

DOI PubMed