H103Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 3 publications
Quick Overview
Human oral squamous cell carcinoma cell line with p53 mutations and HPV-16 presence.
Detailed Summary
The H103 cell line is derived from human oral squamous cell carcinoma and exhibits key characteristics relevant to cancer research. It shows p53 mutations, including a G-T transversion, which is associated with tobacco-related cancers. The cell line also contains low copy number HPV-16 sequences, indicating potential viral involvement in its origin. H103 is immortal, 3T3-independent, and demonstrates anchorage-independent growth, making it a valuable model for studying oral cancer progression and viral interactions. Additionally, it expresses mutant p53 proteins, which may contribute to tumorigenicity and resistance to apoptosis. These features make H103 a useful tool for investigating the molecular mechanisms of oral squamous cell carcinoma.
Research Applications
Cancer ResearchViral Oncogenesisp53 MutationsOral Cancer Modeling
Key Characteristics
Immortal3T3-independentAnchorage-independent growthp53 mutation (G-T transversion)HPV-16 presence (low copy number)
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2457 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, tongue[UBERON:UBERON_0001723] |
Donor Information
| Age | 32 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral tongue |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001346_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gly244Cys (c.730G>T) | Unspecified | - | PubMed=28273451, PubMed=22931248 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
9,10
D13S317
12,13
D16S539
11,12
D18S51
15
D21S11
30
D3S1358
17
D5S818
10,11
D7S820
10
D8S1179
12,13
FGA
21,23
Penta D
9,11
Penta E
20
TH01
8,9
TPOX
8,9
vWA
14,16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53.
Yeudall W.A., Paterson I.C., Patel V., Prime S.S.
Eur. J. Cancer B. Oral Oncol. 31:136-143(1995).
MHC antigen expression in human oral squamous carcinoma cell lines.";
Mutlu S., Matthews J.B., Midda M., Scully C., Prime S.S.
J. Pathol. 165:129-136(1991).