H157Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 3 publications
Quick Overview
Human oral squamous cell carcinoma cell line with p53 mutations and HPV-16 presence.
Detailed Summary
The H157 cell line is derived from human oral squamous cell carcinoma and exhibits key characteristics relevant to cancer research. It expresses mutant p53 proteins, with specific mutations identified in exons 8 and 11. The cell line also shows the presence of HPV-16 sequences at low copy numbers, suggesting a potential interaction between viral and cellular factors in tumorigenesis. H157 demonstrates anchorage independence and is immortal, making it a valuable model for studying oral cancer progression and therapeutic responses. Additionally, it shows variable MHC antigen expression, which may impact immune system interactions.
Research Applications
p53 mutation analysisHPV interaction studiescancer progression modelingimmunological response studies
Key Characteristics
mutant p53 expressionHPV-16 presenceimmortalanchorage independence
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2458 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, buccal mucosa[UBERON:UBERON_0006956] |
Donor Information
| Age | 84 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001347_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg306Ter (c.916C>T) | Heterozygous | Germline | PubMed=16418264 |
| MutationSimple | CDKN2A | p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT) | Unspecified | - | PubMed=23851445 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10
D13S317
8,12
D16S539
11
D18S51
20,22
D21S11
28,29
D3S1358
15,18
D5S818
10,11
D7S820
9
D8S1179
13,15
FGA
19,20
Penta D
12
Penta E
7,11
TH01
9.3
TPOX
8
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53.
Yeudall W.A., Paterson I.C., Patel V., Prime S.S.
Eur. J. Cancer B. Oral Oncol. 31:136-143(1995).
MHC antigen expression in human oral squamous carcinoma cell lines.";
Mutlu S., Matthews J.B., Midda M., Scully C., Prime S.S.
J. Pathol. 165:129-136(1991).