H376Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 2 publications
Quick Overview
Human oral squamous cell carcinoma cell line with p53 mutations and HPV-16 presence.
Detailed Summary
The H376 cell line is derived from untreated human oral squamous cell carcinoma and exhibits key characteristics relevant to cancer research. It expresses mutant p53 protein, with specific mutations identified in exons 7 and 8, suggesting potential roles in tumorigenesis. The cell line also shows the presence of HPV-16 sequences at low copy numbers, indicating possible viral involvement in its development. H376 demonstrates anchorage independence, a hallmark of malignant transformation, and is immortal, making it a valuable model for studying oral cancer progression and therapeutic strategies. Its properties align with other cell lines in this study, which collectively highlight the complexity of p53 mutations and viral interactions in oral carcinogenesis.
Research Applications
p53 mutation analysisHPV-16 detectionanchorage independence studiesoral cancer progression modeling
Key Characteristics
ImmortalAnchorage-independentp53 mutation (exon 7 and 8)HPV-16 presence at low copy number
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2463 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, floor of mouth[UBERON:UBERON_0003679] |
Donor Information
| Age | 40 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001510_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gly266Ter (c.796G>T) | Homozygous | - | Unknown, PubMed=7633286 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
8,11
D16S539
11
D18S51
12,14
D21S11
29,30
D3S1358
15,17
D5S818
10,12
D7S820
8,10
D8S1179
13,17
FGA
19,22
Penta D
12,14
Penta E
7,10
TH01
6,9
TPOX
8
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53.
Yeudall W.A., Paterson I.C., Patel V., Prime S.S.
Eur. J. Cancer B. Oral Oncol. 31:136-143(1995).