H413Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 2 publications
Quick Overview
Human oral squamous cell carcinoma cell line with p53 mutations and HPV-16 presence.
Detailed Summary
The H413 cell line is derived from human oral squamous cell carcinoma and exhibits key characteristics relevant to cancer research. It expresses mutant p53 proteins, with specific mutations identified in exons 8, including a G to A substitution. Additionally, H413 was found to harbor HPV-16 sequences at low copy numbers in early passages, suggesting a potential viral contribution to its tumorigenic properties. The cell line shows anchorage independence and has been used in studies examining the interplay between p53 mutations and viral oncogenesis in oral cancers. H413 is immortal and has been utilized in investigations of tumorigenicity and cellular transformation mechanisms.
Research Applications
p53 mutation analysisHPV-16 detectiontumorigenicity studiescellular transformation mechanisms
Key Characteristics
ImmortalAnchorage-independent growthMutant p53 expressionHPV-16 presence in early passages
Generated on 6/18/2025
Basic Information
| Database ID | CVCL_2465 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, buccal mucosa[UBERON:UBERON_0006956] |
Donor Information
| Age | 53 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001511_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Glu68Gly (c.203A>G) | Heterozygous | - | PubMed=7633286 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
12
D16S539
11
D18S51
18
D21S11
29,33.2
D3S1358
14
D5S818
12
D7S820
9,10
D8S1179
11,13
FGA
23,24
Penta D
13
Penta E
5,7
TH01
6,9.3
TPOX
8,11
vWA
16,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53.
Yeudall W.A., Paterson I.C., Patel V., Prime S.S.
Eur. J. Cancer B. Oral Oncol. 31:136-143(1995).