Karpas-1718Homo sapiens (Human)Cancer cell line
Also known as: K1718, KARPAS 1718, Karpas 1718, KARPAS-1718, Kapas 1718
🤖 AI SummaryBased on 2 publications
Quick Overview
Human B-cell lymphoma cell line with 13q31-q32 amplification
Detailed Summary
Karpas-1718 is a human B-cell lymphoma cell line that has been extensively studied for its genomic characteristics, particularly the amplification at the 13q31-q32 region. This cell line was used in research to identify novel genes within the amplified region, such as C13orf25 (also known as Cl3orf25), which showed parallel expression to the genomic amplification. The cell line has also been involved in studies examining the role of GPC5 and other potential target genes in lymphoma. Research on Karpas-1718 has contributed to understanding the genetic mechanisms underlying lymphoma development and progression.
Research Applications
Genomic amplification analysisGene expression profilingIdentification of candidate oncogenesCharacterization of tumor suppressor genes
Key Characteristics
Amplification at 13q31-q32 regionExpression of C13orf25 (Cl3orf25)Used in studies of lymphoma genetics
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2539 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Splenic marginal zone lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Splenic Marginal Zone Lymphoma |
| OncoTree Code | SMZL |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001533_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11,13
D13S317
8,13
D16S539
11,13
D5S818
11,12
D7S820
8
TH01
6
TPOX
8,11
vWA
14
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Martinez-Climent J.A.
Blood 109:271-280(2007).