Karpas-384Homo sapiens (Human)Cancer cell line
Also known as: KARPAS384, KARPAS 384, Karpas 384
🤖 AI SummaryBased on 1 publications
Quick Overview
T-cell line with CDKN2 deletions for cancer research.
Detailed Summary
Karpas-384 is a T-cell line derived from a patient with leukemic transformation of T-cell non-Hodgkin's lymphoma (T-NHL). This cell line exhibits biallelic deletions of the CDKN2 gene, which is implicated in the pathogenesis of various lymphoid malignancies. The CDKN2 gene, located on chromosome 9p21, functions as a tumor suppressor by regulating the cell cycle. Biallelic deletions of CDKN2 have been associated with the transformation of low-grade NHL to high-grade disease and with increased proliferation in SCID mice. Karpas-384 is used in research to study the role of CDKN2 in lymphoid malignancies and the mechanisms of tumor progression. The cell line was derived by Dr. A. Karpas and is part of a panel of lymphoid cell lines analyzed for CDKN2 abnormalities.
Research Applications
Study of CDKN2 gene deletions in lymphoid malignanciesInvestigation of tumor suppressor gene function in T-cell lymphomasAnalysis of lymphoma transformation mechanisms
Key Characteristics
Biallelic CDKN2 deletionsT-cell lineageLeukemic transformation of T-NHL
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2541 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 48 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Primary cutaneous T-cell lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Adult T-Cell Leukemia/Lymphoma |
| OncoTree Code | ATLL |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001097_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | NRAS | p.Gln61Lys (c.181C>A) | Unspecified | Acquired during resistance selection process | PubMed=26214590 |
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
A new human T-cell lymphoma cell line (Karpas 384) of the T-cell receptor gamma/delta lineage with translocation t(7:14) (p13;q11.2).
Karpas A.
Leukemia 7:1047-1053(1993).
Deletions and rearrangement of CDKN2 in lymphoid malignancy.";
Millar J.L., Catovsky D., Dyer M.J.S.
Blood 85:893-901(1995).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).