LO68Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 4 publications
Quick Overview
Human malignant mesothelioma cell line for cancer research.
Detailed Summary
LO68 is a human malignant mesothelioma cell line derived from pleural effusions. It exhibits a fibroblast-like mesenchymal phenotype in culture and is used in studies investigating exosome biology, immune regulation, and cancer progression. Research on LO68 has identified key proteins involved in exosome-mediated signaling, including those related to angiogenesis, immunoregulation, and metastasis. LO68 is also utilized in studies examining the Hippo signaling pathway and its role in tumor suppression. These findings contribute to understanding the molecular mechanisms of mesothelioma and potential therapeutic targets.
Research Applications
Exosome biologyImmune regulationCancer progressionHippo signaling pathwayTumor suppression
Key Characteristics
Fibroblast-like mesenchymal phenotypeExosome-mediated signalingAngiogenesis-related proteinsImmunoregulatory componentsHippo pathway involvement
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2581 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 57 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | black_or_african_american |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Pleura |
| Subtype | Pleural Mesothelioma, Epithelioid Type |
| OncoTree Code | PLEMESO |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001547_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
11
D16S539
10,12
D18S51
12,15
D19S433
13,15.2
D21S11
30,30.2
D2S1338
20,24
D3S1358
16,18
D5S818
11,13
D7S820
8,10
D8S1179
14
FGA
20,22
TH01
8,9
TPOX
8,11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
A proteomic analysis of the malignant mesothelioma secretome using iTRAQ.
Creaney J., Dick I.M., Leon J.S., Robinson B.W.S.
Cancer Genomics Proteomics 14:103-117(2017).
Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo.
Creaney J., Simpson R.J.
Sci. Rep. 6:32643-32643(2016).
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
Asamura H., Gemma A., Yamada T.
J. Thorac. Oncol. 10:844-851(2015).
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
Powell S.N., Zhou Q., Shen R.-L., Olshen A.B., Rusch V.W., Ladanyi M.
Nat. Genet. 43:668-672(2011).