LUDLU-1Homo sapiens (Human)Cancer cell line

Also known as: LUDLU1, LUDLU 1, Ludlu-1

🤖 AI SummaryBased on 8 publications

Quick Overview

LUDLU-1 is a human lung squamous cell carcinoma cell line used in cancer research.

Detailed Summary

LUDLU-1 is a human lung squamous cell carcinoma cell line derived from a male patient. It is widely used in cancer research for studying the molecular mechanisms of squamous cell carcinoma. The cell line has been characterized for its genomic and transcriptomic profiles, including mutations in key genes such as TP53 and BRCA2. Research on LUDLU-1 has focused on understanding the role of somatic mutations, copy number variations, and gene expression in cancer progression. It has also been used to investigate the effects of DNA repair deficiencies and the potential for targeted therapies. The cell line is part of several large-scale studies, including the Cancer Cell Line Encyclopedia (CCLE) and the TRON Cell Line Portal, which provide comprehensive annotations of its genetic and molecular features.

Research Applications

Genomic and transcriptomic profilingMutation analysisDNA repair deficiency studiesTargeted therapy developmentCancer immunotherapy research

Key Characteristics

Mutations in TP53 and BRCA2Copy number variationsGene expression profilingHLA typing and neo-epitope predictionSomatic mutation analysis

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2582
Species	Homo sapiens (Human)

Donor Information

Age	72
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Lung squamous cell carcinoma
Lineage	Lung
Subtype	Lung Squamous Cell Carcinoma
OncoTree Code	LUSC

DepMap Information

Source Type	ECACC
Source ID	ACH-000390_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Trp (c.742C>T)	Homozygous	Somatic mutation acquired during proliferation	from parent cell line VCaP

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

13,14

D18S51

D21S11

D3S1358

16,18

D5S818

D7S820

10,12

D8S1179

8,15

FGA

Penta D

Penta E

12,19

TH01

TPOX

8,11

vWA

17,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing.

Wood H.M., Belvedere O., Papagiannopoulos K., Ryan A., Rabbitts P.H.

PLoS ONE 8:E78823-E78823(2013).

DOI PubMed PMC

Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.

Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.

Br. J. Cancer 109:1599-1608(2013).

DOI PubMed PMC

The transcriptional consequences of somatic amplifications, deletions, and rearrangements in a human lung squamous cell carcinoma.

Papagiannopoulos K., Rabbitts P.H.

Neoplasia 14:1075-1086(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Frequency and extent of allelic loss in the short arm of chromosome 3 in nonsmall-cell lung cancer.

Wells F., Albertson D.G., Waters J., Bergh J.

Genes Chromosomes Cancer 1:95-105(1989).

DOI PubMed