MCC13Homo sapiens (Human)Cancer cell line

Also known as: MCC13 TC, MCC13TC

🤖 AI SummaryBased on 11 publications

Quick Overview

MCC13 is a human Merkel cell carcinoma cell line derived from a Merkel cell carcinoma tumor, used for studying viral oncogenesi...

Detailed Summary

MCC13 is a human cell line derived from a Merkel cell carcinoma (MCC) tumor, commonly used in cancer research to study the molecular mechanisms underlying this aggressive skin cancer. It is known for its expression of viral T antigens and its role in investigating the interaction between the Merkel cell polyomavirus (MCV) and cellular pathways. Research on MCC13 has contributed to understanding the role of MCV in tumorigenesis and the impact of viral oncoproteins on cellular processes. The cell line is also utilized to study the activation of signaling pathways such as PI3K/AKT and the role of p53 in MCC progression. Additionally, MCC13 has been used to analyze chromosomal abnormalities and genetic mutations associated with MCC, providing insights into the genetic basis of this disease.

Research Applications

Viral oncogenesisCellular mechanisms in cancerPI3K/AKT pathway activationp53 function in MCCChromosomal abnormalitiesGenetic mutations in MCC

Key Characteristics

Expresses viral T antigensUsed for studying MCV interactionsRelevant for understanding MCC pathogenesisUtilized in genomic and proteomic studies

Generated on 6/19/2025

Basic Information

Database ID	CVCL_2583
Species	Homo sapiens (Human)
Tissue Source	Cervical lymph node[UBERON:UBERON_0002429]

Donor Information

Age	80
Age Category	Adult
Sex	Female

Disease Information

Disease	Cutaneous neuroendocrine carcinoma
Lineage	Skin
Subtype	Merkel Cell Carcinoma
OncoTree Code	MCC

DepMap Information

Source Type	Sigma-Aldrich
Source ID	ACH-001550_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Pro278Ser (c.832C>T)	Unspecified	-	PubMed=24662767, PubMed=21602893
MutationSimple	TP53	p.Ser241Pro (c.721T>C)	Unspecified	-	PubMed=11216673

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

9,11

D18S51

16,17

D19S433

D21S11

30,31

D2S1338

19,20

D3S1358

16,18

D5S818

9,12

D7S820

D8S1179

13,14

FGA

19,20

Penta D

13,14

Penta E

11,14

TH01

7,9.3

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.

Mitulovic G.

Clin. Proteomics 16:42.1-42.13(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.

Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.

J. Invest. Dermatol. 133:2453-2460(2013).

DOI PubMed

Activation of the PI3K/AKT pathway in Merkel cell carcinoma.";

Landthaler M., Becker J.C.

PLoS ONE 7:E31255-E31255(2012).

DOI PubMed PMC

Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.

Moore P.S., Becker J.C.

J. Virol. 84:7064-7072(2010).

DOI PubMed PMC

Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.

Cocquyt V.F., Salwen H.R., De Paepe A., Speleman F.

Int. J. Cancer 101:137-145(2002).

DOI PubMed

Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.

Speleman F., Sturm R.A.

Int. J. Cancer 101:103-110(2002).

DOI PubMed

CDKN2A is not the principal target of deletions on the short arm of chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin.

Baumann K.C., Hayward N.K., Leonard J.H.

Int. J. Cancer 93:361-367(2001).

DOI PubMed

Mutation analysis of P73 and TP53 in Merkel cell carcinoma.";

De Wolf-Peeters C., De Paepe A., Caput D., Speleman F.

Br. J. Cancer 82:823-826(2000).

DOI PubMed PMC

A nonconsensus octamer-recognition sequence (TAATGARAT-motif) identifies a novel DNA binding protein in human Merkel cell carcinoma cell lines.

Thomson J.A.F., Leonard J.H., McGregor K., Sturm R.A., Parsons P.G.

Int. J. Cancer 58:285-290(1994).

DOI PubMed

Characterisation of four Merkel cell carcinoma adherent cell lines.";

Leonard J.H., Dash P., Holland P., Kearsley J.H., Bell J.R.

Int. J. Cancer 60:100-107(1995).

DOI PubMed