MCC14/2Homo sapiens (Human)Cancer cell line
Also known as: MCC142, MCC14/2 TC, MCC14/2TC, MCC14-2
🤖 AI SummaryBased on 5 publications
Quick Overview
MCC14/2 is a human Merkel cell carcinoma cell line used in cancer research.
Detailed Summary
MCC14/2 is a human cell line derived from Merkel cell carcinoma (MCC), a rare and aggressive form of skin cancer. It is one of several MCC cell lines established for research purposes, including studies on genetic mutations, neuroendocrine markers, and tumor biology. The cell line is characterized by its adherence to culture surfaces and its expression of certain neuroendocrine markers, though it lacks some features seen in other MCC lines. Research on MCC14/2 has contributed to understanding the molecular mechanisms of MCC, including the role of transcription factors like Brn-3c and HATH1, and the potential involvement of genes such as CDKN2A and TP53 in tumorigenesis. The cell line is used in studies related to neuroendocrine differentiation, tumor progression, and therapeutic strategies for MCC.
Research Applications
Cancer researchNeuroendocrine differentiationGenetic mutation analysisTumor biologyTherapeutic strategies
Key Characteristics
Adherent cell lineExpresses neuroendocrine markersInvolvement in CDKN2A and TP53 studiesExpression of Brn-3c and HATH1
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2584 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Iliac lymph node[UBERON:UBERON_0015878] |
Donor Information
| Age | 80 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Cutaneous neuroendocrine carcinoma |
|---|---|
| Lineage | Skin |
| Subtype | Merkel Cell Carcinoma |
| OncoTree Code | MCC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001551_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Val272Glu (c.815T>A) | Unspecified | - | Unknown, PubMed=10732753 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
13
D16S539
13
D18S51
12,15,17
D19S433
12,14
D21S11
29,32.2
D2S1338
19
D3S1358
16
D5S818
13
D7S820
8,10
D8S1179
10,14
FGA
21
Penta D
9,12
Penta E
7
TH01
6,9.3
TPOX
8
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.
Speleman F., Sturm R.A.
Int. J. Cancer 101:103-110(2002).
CDKN2A is not the principal target of deletions on the short arm of chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin.
Baumann K.C., Hayward N.K., Leonard J.H.
Int. J. Cancer 93:361-367(2001).
Mutation analysis of P73 and TP53 in Merkel cell carcinoma.";
De Wolf-Peeters C., De Paepe A., Caput D., Speleman F.
Br. J. Cancer 82:823-826(2000).
A nonconsensus octamer-recognition sequence (TAATGARAT-motif) identifies a novel DNA binding protein in human Merkel cell carcinoma cell lines.
Thomson J.A.F., Leonard J.H., McGregor K., Sturm R.A., Parsons P.G.
Int. J. Cancer 58:285-290(1994).