MCC26Homo sapiens (Human)Cancer cell line
Also known as: MCC26 TC, MCC26TC
🤖 AI SummaryBased on 6 publications
Quick Overview
MCC26 is a human Merkel cell carcinoma cell line used in cancer research.
Detailed Summary
MCC26 is a human Merkel cell carcinoma (MCC) cell line derived from a tumor in a 8-year-old woman. It is used in research to study the molecular mechanisms of MCC, including the role of the PI3K/AKT pathway and the impact of the Merkel cell polyoma virus (MCV). The cell line exhibits high levels of AKT phosphorylation, suggesting activation of the PI3K/AKT pathway. Additionally, MCC26 has been used to investigate the effects of genetic mutations and the response to therapeutic inhibitors. The cell line is part of a panel of MCC cell lines that contribute to understanding the genetic and molecular basis of this aggressive skin cancer.
Research Applications
Molecular mechanisms of MCCPI3K/AKT pathway activationMCV infection and its role in MCCGenetic mutations in MCCTherapeutic response to inhibitors
Key Characteristics
High AKT phosphorylationMCV-positive statusUsed in drug response studies
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2585 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 82 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Cutaneous neuroendocrine carcinoma |
|---|---|
| Lineage | Skin |
| Subtype | Merkel Cell Carcinoma |
| OncoTree Code | MCC |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001552_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | RB1 | p.Arg556Ter (c.1666C>T) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | HRAS | p.Gly12Asp (c.35G>A) | Heterozygous | - | from parent cell line SUM159PT |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
13,14
D16S539
11,13
D18S51
15,18
D19S433
16
D21S11
31,32.2
D2S1338
23,26
D3S1358
17
D5S818
12
D7S820
8,9
D8S1179
8,10
FGA
24,25
Penta D
12,14
Penta E
11,14
TH01
9.3
TPOX
8
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
J. Invest. Dermatol. 133:2453-2460(2013).
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.";
Landthaler M., Becker J.C.
PLoS ONE 7:E31255-E31255(2012).
Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.
Cocquyt V.F., Salwen H.R., De Paepe A., Speleman F.
Int. J. Cancer 101:137-145(2002).
Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.
Speleman F., Sturm R.A.
Int. J. Cancer 101:103-110(2002).