Mero-14Homo sapiens (Human)Cancer cell line
Also known as: MERO14
🤖 AI SummaryBased on 3 publications
Quick Overview
Human malignant mesothelioma cell line for cancer research.
Detailed Summary
Mero-14 is a human malignant mesothelioma cell line established from pleural effusion and autopsy material. It exhibits a spindle-shaped morphology with hyperdiploid karyotype, similar to primary tumor cells. The cell line shows abnormal cytogenetics, including marker chromosomes 1, 3, 9, and 22. Mero-14 expresses intermediate filaments such as vimentin and cytokeratins 7, 8, 18, and 19, which are consistent with mesothelial origin. Growth characteristics indicate that Mero-14 is sensitive to epidermal growth factor (EGF) and hydrocortisone (HC), with EGF alone slightly enhancing proliferation. The cell line has been used in studies investigating the Hippo signaling pathway and genetic alterations in mesothelioma. Mero-14 is also utilized in research on tumor suppressor genes and oncogene expression, contributing to understanding the molecular mechanisms of mesothelioma progression.
Research Applications
Cancer researchMalignant mesothelioma studiesHippo signaling pathway investigationGenetic alterations in mesotheliomaTumor suppressor gene analysisOncogene expression studies
Key Characteristics
Spindle-shaped morphologyHyperdiploid karyotypeMarker chromosomes 1, 3, 9, and 22Intermediate filament expression (vimentin, cytokeratins 7, 8, 18, 19)Sensitivity to EGF and HCAbnormal cytogenetics
Generated on 6/19/2025
Basic Information
| Database ID | CVCL_2590 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 60 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Pleura |
| Subtype | Pleural Mesothelioma, Epithelioid Type |
| OncoTree Code | PLEMESO |
DepMap Information
| Source Type | Sigma-Aldrich |
|---|---|
| Source ID | ACH-001555_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
12
D16S539
12,13
D18S51
19
D21S11
31
D3S1358
14
D5S818
9
D7S820
10,11
D8S1179
10
FGA
21,23
Penta D
12,13
Penta E
7,12
TH01
8
TPOX
9,11
vWA
15,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
Asamura H., Gemma A., Yamada T.
J. Thorac. Oncol. 10:844-851(2015).
Characterization of three human malignant mesothelioma cell lines.";
van der Kwast T.H., Delahaye M., Schaart G., Ramaekers F.C.S.
Cancer Genet. Cytogenet. 42:115-128(1989).